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GTF2I Knockout Cell Lines

Gene: GTF2I

Official Full Name: general transcription factor IIiprovided by HGNC

Gene Summary: This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07495 GTF2I Knockout cell line (HeLa) Human GTF2I 1:3~1:6 Negative Online Inquiry
KO07496 GTF2I Knockout cell line (HCT 116) Human GTF2I 1:2~1:4 Negative Online Inquiry
KO07497 GTF2I Knockout cell line (HEK293) Human GTF2I 1:3~1:6 Negative Online Inquiry
KO07498 GTF2I Knockout cell line (A549) Human GTF2I 1:3~1:4 Negative Online Inquiry

Background

GTF2I Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate research into the function of the GTF2I gene, which encodes a member of the general transcription factor II family. By employing CRISPR-Cas9 technology, these cell lines have had the GTF2I gene effectively disrupted, allowing for the examination of its role in various cellular processes such as gene expression regulation, cellular signaling pathways, and their implications in conditions like cancer and developmental disorders.

The primary function of these knockout cell lines is to serve as a versatile platform for studying the biological consequences of GTF2I haploinsufficiency and complete loss of function. Researchers can utilize these cells to perform functional assays, gene expression profiling, and even drug response studies, thus uncovering the molecular mechanisms tied to GTF2I dysregulation. This understanding is vital, given that aberrations in GTF2I have been implicated in multiple pathologies, including immune system disorders and neurodevelopmental conditions.

The scientific importance of GTF2I Gene Knockout Cell Lines extends beyond basic research; they are also invaluable for therapeutic development and drug testing. These models provide a unique opportunity to identify potential therapeutic targets and evaluate the efficacy of new compounds designed to modulate GTF2I-related pathways, supporting both academic and pharmaceutical research efforts.

One of the standout advantages of our GTF2I Gene Knockout Cell Lines is their robustness and reproducibility, validated across multiple experiments and laboratory conditions. Unlike conventional knockdown methods that often provide transient effects, our knockout cell lines offer stable genetic disruption, yielding consistent results that can be confidently communicated in research findings.

For researchers and clinicians alike, these cell lines represent a powerful tool to explore the complexities of gene function and its implications in human health. Our product not only meets the demand for advanced genomic tools but also empowers scientists to make impactful contributions to their fields.

Our company specializes in providing high-quality biological products, ensuring that researchers have access to cutting-edge tools designed to accelerate discovery and innovation. With a commitment to excellence and a deep understanding of genetic engineering, we continue to support the scientific community with resources that enhance research capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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