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GTF2H2C_2 Knockout Cell Lines

Gene: GTF2H2C_2

Official Full Name: GTF2H2 family member C, copy 2provided by HGNC

Gene Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17229 GTF2H2C_2 Knockout cell line (HeLa) Human GTF2H2C_2 1:3~1:6 Negative Online Inquiry
KO17230 GTF2H2C_2 Knockout cell line (HCT 116) Human GTF2H2C_2 1:2~1:4 Negative Online Inquiry
KO17231 GTF2H2C_2 Knockout cell line (HEK293) Human GTF2H2C_2 1:3~1:6 Negative Online Inquiry
KO17232 GTF2H2C_2 Knockout cell line (A549) Human GTF2H2C_2 1:3~1:4 Negative Online Inquiry

Background

GTF2H2C_2 Gene Knockout Cell Lines are specialized cellular models designed to study the biological functions and regulatory mechanisms associated with the GTF2H2C_2 gene, which is known for its role in transcriptional regulation and cellular response to DNA damage. These cell lines have undergone targeted gene editing to completely disrupt the expression of GTF2H2C_2, enabling researchers to observe the resulting phenotypic and molecular changes that occur in the absence of this gene.

The fundamental mechanism by which the GTF2H2C_2 knockout operates involves the loss of its contribution to the transcription factor complex, which is essential for initiating RNA synthesis. Consequently, the knockout cell lines serve as a critical tool for investigating the gene's role in cellular proliferation, apoptosis, and DNA repair mechanisms. By analyzing the biochemical pathways altered in these knockout models, researchers can uncover insights into the gene's contribution to various cellular processes and disease states.

In a research setting, these cell lines offer substantial value for understanding the molecular underpinnings of conditions such as cancer, neurodegenerative diseases, and other disorders linked to transcriptional dysregulation. Clinically, the implications of studying GTF2H2C_2 are profound, as they may lead to the identification of novel therapeutic targets or biomarkers.

The specific advantages of GTF2H2C_2 Gene Knockout Cell Lines compared to traditional methods, such as temporary gene silencing, include stable gene disruption, which allows for long-term studies without the confounding variance of transient expression changes. Additionally, our cell lines come with rigorous validation for genetic loss and reproducibility, ensuring reliable results in experiments.

Researchers and clinicians will find that these knockout cell lines are invaluable for advancing knowledge in gene function and disease pathology. By incorporating these models into their studies, they can enhance their capacity to develop innovative strategies for therapeutic intervention.

Our company prides itself on its expertise in producing high-quality genetic models tailored for cutting-edge research. Our commitment to scientific excellence and technological advancement ensures that researchers have access to the best tools for unlocking the mysteries of gene regulation and function.

Please note that all services are for research use only. Not intended for any clinical use.

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