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GSKIP Knockout Cell Lines

Gene: GSKIP

Official Full Name: GSK3B interacting proteinprovided by HGNC

Gene Summary: This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00887 GSKIP Knockout cell line(HCT 116) Human GSKIP 1:2~1:4 Negative Online Inquiry
KO17237 GSKIP Knockout cell line (HeLa) Human GSKIP 1:3~1:6 Negative Online Inquiry
KO17238 GSKIP Knockout cell line (HEK293) Human GSKIP 1:3~1:6 Negative Online Inquiry
KO17239 GSKIP Knockout cell line (A549) Human GSKIP 1:3~1:4 Negative Online Inquiry

Background

GSKIP Gene Knockout Cell Lines are expertly crafted cellular models that facilitate the precise investigation of gene function by creating targeted disruptions in specific genes. Utilizing state-of-the-art CRISPR/Cas9 technology, these cell lines are engineered to eliminate the expression of designated genes, allowing researchers to study the resultant phenotypic changes and gain insights into gene expression, regulatory mechanisms, and cellular pathways.

The key function of GSKIP Gene Knockout Cell Lines lies in their ability to provide a controlled environment for functional genomics studies. By introducing gene knockouts, scientists can observe the effects on cellular behavior, drug response, and disease progression, particularly in fields such as cancer research, metabolic disorders, and genetic diseases. This technology significantly enhances our understanding of pathophysiology and aids in identifying potential therapeutic targets.

The scientific importance of these cell lines extends to both research and clinical applications. They serve as indispensable tools for validating gene function, optimizing drug screening processes, and developing gene therapies. Moreover, the data derived from these models can help accelerate the transition from basic research to clinical trials, thereby fostering innovation in treatment strategies.

What sets GSKIP Gene Knockout Cell Lines apart from alternative products is their unmatched specificity and reliability. Each cell line undergoes rigorous validation to ensure high knockout efficiency and minimal off-target effects. This attention to detail translates into reproducible results and substantial time saving in experimental workflows, making GSKIP a preferred choice for researchers navigating complex genetic inquiries.

By choosing GSKIP Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful resource that not only enhances experimental rigor but also accelerates progress towards groundbreaking discoveries. Our team's extensive expertise in molecular biology and commitment to advancing research capabilities affirm our position as a trusted provider of innovative biological products designed to empower researchers in their quest for scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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