Gene: GPX2
Official Full Name: glutathione peroxidase 2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37524 | GPX2 Knockout cell line (A549) | Human | GPX2 | 1:3~1:4 | Negative | Online Inquiry |
GPX2 Gene Knockout Cell Lines are a valuable tool in molecular biology, specifically designed to study the role of the glutathione peroxidase 2 (GPX2) gene in various biological processes. These cell lines are generated using advanced CRISPR/Cas9 gene editing technology, effectively silencing the GPX2 gene to enable researchers to investigate its function in cellular stress responses, oxidative damage, and tumorigenesis among other physiological processes.
The principal function of GPX2 is to provide antioxidant defense by reducing hydrogen peroxide and lipid peroxides, thereby maintaining cellular redox homeostasis. By utilizing GPX2 knockout cell lines, scientists can elucidate the consequences of GPX2 deficiency on cellular metabolism, signaling pathways, and gene expression patterns. They serve as an indispensable model system for exploring the mechanisms by which oxidative stress influences the development of a range of conditions—from cancer to neurodegenerative diseases.
In terms of scientific importance, these cell lines enable targeted research that contributes to the understanding of redox biology and its implications in health and disease. The insights gained can facilitate the development of novel therapeutic strategies to combat oxidative-related pathologies.
Compared to traditional knockdown methodologies, GPX2 Gene Knockout Cell Lines provide a more permanent and stable genetic alteration, allowing for more reproducible results and the ability to conduct long-term experiments. This durability is a unique selling point that enhances experimental reliability and promotes more significant findings.
For researchers and clinicians, the value of utilizing GPX2 knockout cell lines lies in their capacity to deepen our understanding of oxidative stress responses and their intricate connections to various diseases. This research could potentially guide the development of antioxidant therapies and inform clinical approaches to treatment.
Our company specializes in providing top-tier biological products, supported by cutting-edge technology and extensive expertise in gene editing and cellular models. By offering high-quality GPX2 Gene Knockout Cell Lines, we empower the scientific community to push the boundaries of current understanding in cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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