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GPRC5A Knockout Cell Lines

Gene: GPRC5A

Official Full Name: G protein-coupled receptor class C group 5 member Aprovided by HGNC

Gene Summary: This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03834 GPRC5A Knockout cell line (HeLa) Human GPRC5A 1:3~1:6 Negative Online Inquiry
KO03835 GPRC5A Knockout cell line (HCT 116) Human GPRC5A 1:2~1:4 Negative Online Inquiry
KO03836 GPRC5A Knockout cell line (HEK293) Human GPRC5A 1:3~1:6 Negative Online Inquiry
KO03837 GPRC5A Knockout cell line (A549) Human GPRC5A 1:3~1:4 Negative Online Inquiry

Background

GPRC5A Gene Knockout Cell Lines represent a significant resource for researchers exploring the physiological and pathological roles of the GPRC5A gene, a member of the G protein-coupled receptor family. These cell lines have been genetically modified to eliminate the expression of GPRC5A, allowing for in-depth studies of its function in various biological processes, including cell signaling, differentiation, and tumorigenesis.

The core mechanism of these knockout cell lines involves the precise ablation of GPRC5A through techniques such as CRISPR-Cas9 gene editing. This approach ensures that the resultant cell lines exhibit a definitive loss of GPRC5A activity, enabling researchers to study the resultant phenotypes and cellular responses. By assessing how these cell lines behave under normal and pathological conditions, scientists can elucidate the receptor's contributions to cancer biology, immune response, and other crucial areas of health and disease.

The scientific importance of GPRC5A Gene Knockout Cell Lines lies in their wide-ranging applications. They are invaluable for drug discovery and development, providing a platform for screening compounds that target GPRC5A-related pathways. Additionally, these lines facilitate the investigation of pharmacogenomics, allowing researchers to examine how variations in GPRC5A expression and function could influence individual responses to therapies.

Compared to alternative models such as wild-type cell lines or transgenic animals, GPRC5A Gene Knockout Cell Lines offer a more controlled environment to dissect GPRC5A functions specifically, saving time and resources. Their adaptability for high-throughput screening further enhances their appeal for pharmaceutical research.

For researchers and clinicians vested in uncovering the complexities of receptor biology, these knockout cell lines deliver a unique advantage that accelerates discovery and translation into clinical applications. Our company is committed to enhancing research efficiency and innovation by providing high-quality genetic tools like GPRC5A Gene Knockout Cell Lines, grounded in scientific expertise and a deep understanding of biological research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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