Gene: GPR37
Official Full Name: G protein-coupled receptor 37provided by HGNC
Gene Summary: This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01797 | GPR37 Knockout cell line (HeLa) | Human | GPR37 | 1:3~1:6 | Negative | Online Inquiry |
KO01798 | GPR37 Knockout cell line (HCT 116) | Human | GPR37 | 1:2~1:4 | Negative | Online Inquiry |
KO01799 | GPR37 Knockout cell line (HEK293) | Human | GPR37 | 1:3~1:6 | Negative | Online Inquiry |
GPR37 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the GPR37 gene, which encodes for the protein known as the "parkin-associated endothelin-like receptor." This innovative biological product serves as a crucial tool for researchers studying neurodegenerative diseases, as GPR37 has been implicated in the pathology of conditions such as Parkinson's disease and other neurodegenerative disorders.
The primary function of these knockout cell lines is to provide a controlled environment in which researchers can investigate the role of GPR37 in cellular signaling pathways, protein interactions, and cellular responses to various stimuli. By eliminating the gene's expression, scientists can analyze the consequences of its absence, thereby elucidating its biological relevance and potential therapeutic targets. This model facilitates a clearer understanding of mechanisms underlying neuroinflammation, neuronal cell death, and synaptic dysfunction.
The scientific importance of GPR37 Gene Knockout Cell Lines extends into both research and clinical realms. In research, these cell lines enable the exploration of fundamental biological processes and may aid in the development of novel drugs or therapeutic approaches. Clinically, findings derived from studies using these cell lines could contribute to better diagnostic and prognostic tools for neurodegenerative diseases.
Compared to traditional cell lines, the GPR37 knockout models offer unmatched specificity and relevance for studying GPR37-related signaling pathways. Other cell lines may not accurately mimic the conditions associated with the loss of GPR37 function, whereas our product ensures that researchers work with a precise representation of the gene's challenges.
For researchers and clinicians focused on neurobiology and pharmacology, the value of GPR37 Gene Knockout Cell Lines lies in their ability to provide insights that could lead to groundbreaking discoveries and advancements in the treatment of neurodegenerative diseases. Our commitment to quality and innovation is underscored by our expertise in genetic engineering and cell line development, making us a reliable partner for advancing your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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