Gene: GPBP1
Official Full Name: GC-rich promoter binding protein 1provided by HGNC
Gene Summary: This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17315 | GPBP1 Knockout cell line (HeLa) | Human | GPBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO17316 | GPBP1 Knockout cell line (HCT 116) | Human | GPBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO17317 | GPBP1 Knockout cell line (HEK293) | Human | GPBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO17318 | GPBP1 Knockout cell line (A549) | Human | GPBP1 | 1:3~1:4 | Negative | Online Inquiry |
GPBP1 Gene Knockout Cell Lines are specifically engineered cell lines that lack the expression of the Gene-binding Protein 1 (GPBP1). GPBP1 is a transcription factor crucial in regulating gene expression involved in various cellular processes, including stress responses and cell proliferation. These knockout cell lines are instrumental for researchers investigating the functional roles of GPBP1 in biological pathways, providing an ideal model to elucidate the gene’s impact on cellular behavior and interactions.
The key mechanism behind these cell lines is the targeted gene editing using CRISPR-Cas9 technology, which precisely disrupts the GPBP1 gene, resulting in a complete loss of protein function. This enables scientists to explore the resulting phenotypic changes, signaling pathways, and gene regulatory networks, allowing for a clearer understanding of how GPBP1 contributes to various physiological and pathological states, including cancer biology and neurodegenerative diseases.
The scientific importance of GPBP1 Gene Knockout Cell Lines cannot be overstated. In research settings, they serve as a robust tool to study gene function in human cells, making them highly relevant for translational science. Clinically, they can facilitate drug discovery efforts by offering insights into potential target genes and novel therapeutic avenues.
Compared to alternative models, such as overexpressing or wild-type cell lines, GPBP1 knockout cell lines provide a more accurate representation of loss-of-function scenarios, delivering data that may be critical in developing targeted therapies. Additionally, these cell lines can complement existing experimental designs, giving researchers the flexibility to tailor their investigations.
For researchers and clinicians aiming to expand their understanding of GPBP1 and its role within complex biological systems, these knockout cell lines represent a valuable resource. The ability to manipulate and study gene function directly meets the ongoing demand for innovative tools that drive scientific discovery.
At [Your Company Name], we pride ourselves on our commitment to advancing biological research. With our state-of-the-art gene editing technology and a deep understanding of cellular mechanisms, we offer high-quality GPBP1 Gene Knockout Cell Lines, empowering scientists to uncover new insights into gene regulation and its implications for health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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