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GNB2 Knockout Cell Lines

Gene: GNB2

Official Full Name: G protein subunit beta 2provided by HGNC

Gene Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01341 GNB2 Knockout cell line (HeLa) Human GNB2 1:3~1:6 Negative Online Inquiry
KO10343 GNB2 Knockout cell line (HCT 116) Human GNB2 1:2~1:4 Negative Online Inquiry
KO10344 GNB2 Knockout cell line (HEK293) Human GNB2 1:3~1:6 Negative Online Inquiry
KO10345 GNB2 Knockout cell line (A549) Human GNB2 1:3~1:4 Negative Online Inquiry

Background

GNB2 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the GNB2 gene, which encodes for the beta subunit of heterotrimeric G-proteins. These knockout lines provide researchers with a powerful tool to study the G-protein signaling pathways crucial in a myriad of physiological processes, including cell proliferation, differentiation, and apoptosis. By removing the GNB2 gene, scientists can elucidate its specific role and observe the downstream effects on cellular signaling mechanisms, offering insights into its contributions to various diseases, particularly cancer and metabolic disorders.

The principal mechanism by which GNB2 knockout cells operate involves the disruption of G-protein coupled receptor (GPCR) signaling pathways. Without GNB2, the interaction between GPCRs and their associated G-proteins is compromised, allowing for the assessment of GNB2's role in mediating cellular responses to external stimuli. This makes GNB2 knockout cell lines invaluable in both basic and applied research settings, facilitating studies that could lead to novel therapeutic targets or biomarker discovery.

One of the key advantages of our GNB2 Gene Knockout Cell Lines is their high specificity and reproducibility, features critical for obtaining reliable data. Unlike other gene editing techniques that may produce off-target effects, our knockout lines ensure that the precise gene of interest is ablated, enabling clearer interpretations of experimental outcomes. This specificity minimizes variability and enhances the reliability of experimental results, making these cell lines exceptionally valuable to researchers across various disciplines, including pharmacology, molecular biology, and pathology.

Furthermore, these knockout cell lines can be easily incorporated into various experimental designs, including drug screening assays, signal transduction studies, and genetic interaction mapping, thus bridging the gap between basic research and clinical application. Researchers, clinicians, and pharmaceutical companies will find that GNB2 Gene Knockout Cell Lines are an essential addition to their toolkit for advancing scientific knowledge and developing new therapies.

At [Your Company Name], we pride ourselves on delivering cutting-edge biological products that enhance research capabilities. Our expertise in gene editing technology ensures the highest quality and performance of our GNB2 Gene Knockout Cell Lines, aligning with our commitment to supporting the scientific community in their quest for innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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