Gene: GNAI2
Official Full Name: G protein subunit alpha i2provided by HGNC
Gene Summary: The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08746 | GNAI2 Knockout cell line (HeLa) | Human | GNAI2 | 1:3~1:6 | Negative | Online Inquiry |
KO08747 | GNAI2 Knockout cell line (HCT 116) | Human | GNAI2 | 1:2~1:4 | Negative | Online Inquiry |
KO08748 | GNAI2 Knockout cell line (HEK293) | Human | GNAI2 | 1:3~1:6 | Negative | Online Inquiry |
KO08749 | GNAI2 Knockout cell line (A549) | Human | GNAI2 | 1:3~1:4 | Negative | Online Inquiry |
GNAI2 Gene Knockout Cell Lines are genetically engineered cell lines in which the GNAI2 gene has been specifically disrupted or rendered non-functional. This manipulation allows for the investigation of the gene's role in cellular processes and its involvement in various pathological conditions. GNAI2, part of the G protein alpha subunit family, plays a pivotal role in transducing signals from cell surface receptors to intracellular pathways, influencing a range of physiological functions including hormone secretion, cell proliferation, and signal transduction.
The key function of GNAI2 knockout cell lines lies in their ability to facilitate the study of GNAI2-related signaling cascades and their implications in diseases, such as cancer and metabolic disorders. By utilizing these cell lines, researchers can elucidate the downstream effects of GNAI2 loss, examine compensatory mechanisms, and identify potential therapeutic targets. Furthermore, these models enable the exploration of the G protein signaling networks, offering insights that could lead to novel interventions.
The scientific importance of GNAI2 gene knockout cell lines extends to both research and clinical settings. They are invaluable for drug discovery, enabling high-throughput screening of compounds that may interact with GNAI2 signaling pathways. In terms of applications, they can support studies on gene function, the role of G proteins in specific disease mechanisms, and the effectiveness of potential therapeutic agents.
What sets GNAI2 gene knockout cell lines apart from traditional models is their specificity and precision. Unlike broad pharmacological inhibition, which can produce off-target effects, these cell lines provide clear and unambiguous insights into the consequences of GNAI2 loss. This specificity significantly enhances the credibility of experimental findings and aids in the development of targeted therapies.
For researchers and clinicians seeking to deepen their understanding of GNAI2-related pathways, these knockout cell lines represent a robust platform. Their value stems not only from the clarity they offer in mechanistic studies but also from their potential to advance therapeutic applications, particularly in conditions where GNAI2 dysregulation contributes to disease pathology.
Our company specializes in providing high-quality biological products and gene-editing services, ensuring that researchers have access to the tools necessary to advance their work in molecular biology and genetics. With our expertise in genetic engineering and cell line development, we are committed to supporting the scientific community in uncovering novel insights and driving innovations in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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