Gene: GIT2
Official Full Name: GIT ArfGAP 2provided by HGNC
Gene Summary: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32704 | GIT2 Knockout cell line (HeLa) | Human | GIT2 | 1:3~1:6 | Negative | Online Inquiry |
KO32705 | GIT2 Knockout cell line (HCT 116) | Human | GIT2 | 1:2~1:4 | Negative | Online Inquiry |
KO32706 | GIT2 Knockout cell line (HEK293) | Human | GIT2 | 1:3~1:6 | Negative | Online Inquiry |
KO32707 | GIT2 Knockout cell line (A549) | Human | GIT2 | 1:3~1:4 | Negative | Online Inquiry |
GIT2 gene knockout cell lines are specialized cellular tools that have been genetically modified to disable the expression of the GIT2 gene, which encodes for a key regulatory protein involved in various signaling pathways. This innovative product serves as an invaluable resource for researchers exploring cellular mechanisms related to adhesion, migration, and various pathways associated with cancer and metabolic diseases. The knockout of GIT2 offers unprecedented insight into its role in cellular functions by allowing scientists to observe changes in behavior and physiology in a controlled environment.
The primary function of GIT2 gene knockout cell lines lies in their ability to elucidate the biological impact of GIT2 deficiency. By disrupting the normal GIT2-mediated signaling pathways, researchers can systematically investigate the downstream effects on cell proliferation, motility, and apoptosis. The mechanisms by which these cell lines operate include the alteration of protein interactions and signal transduction cascades, making them critical in studies related to disease mechanisms and drug responses.
From a scientific perspective, the applications of GIT2 gene knockout cell lines are extensive. They are particularly valuable in cancer research, where the modulation of cell signaling pathways is key to understanding tumor evolution and metastasis. Additionally, these cell lines can be utilized in exploring the role of GIT2 in various metabolic disorders, enhancing our understanding of cellular metabolism and potential therapeutic targets.
One of the significant advantages of using GIT2 gene knockout cell lines lies in their specificity and reproducibility compared to other genetic manipulation methods, such as CRISPR or RNA interference, which can produce off-target effects. These knockout models provide clarity and precision, allowing researchers to confidently draw conclusions about the role of the GIT2 gene without extraneous variables.
In summary, GIT2 gene knockout cell lines offer unparalleled value to researchers and clinicians by facilitating in-depth studies of critical cellular processes. Their ability to enhance our understanding of GIT2-related pathways and disease mechanisms positions them as essential tools in advancing biological research. As a company committed to supporting scientific innovation, we take pride in our comprehensive portfolio of genetically modified cell lines, empowering scientists to accelerate discoveries and improve clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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