Gene: GGA2
Official Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by HGNC
Gene Summary: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29914 | GGA2 Knockout cell line (HeLa) | Human | GGA2 | 1:3~1:6 | Negative | Online Inquiry |
KO29915 | GGA2 Knockout cell line (HCT 116) | Human | GGA2 | 1:2~1:4 | Negative | Online Inquiry |
KO29916 | GGA2 Knockout cell line (HEK293) | Human | GGA2 | 1:3~1:6 | Negative | Online Inquiry |
KO29917 | GGA2 Knockout cell line (A549) | Human | GGA2 | 1:3~1:4 | Negative | Online Inquiry |
GGA2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the GGA2 gene, an essential component involved in intracellular transport and protein sorting pathways. These genetically modified cell lines serve as pivotal tools in understanding the role of GGA2 in cellular functions such as vesicle trafficking, endocytosis, and signal transduction. By selectively knocking out the GGA2 gene, researchers can elucidate its contributions to various biological processes and its implications in diseases, such as cancer and neurodegenerative disorders.
The primary function of GGA2 is to facilitate the sorting of protein cargoes through the trans-Golgi network and influence the recycling pathways of receptors within cells. By utilizing GGA2 Gene Knockout Cell Lines, scientists can investigate the downstream effects of GGA2 loss on cellular homeostasis, allowing for comprehensive studies on protein misfolding and cellular signaling dynamics. Moreover, these cell lines can be utilized in drug discovery, enabling the assessment of therapeutic interventions that target GGA2-associated pathways.
The scientific importance of GGA2 Gene Knockout Cell Lines is underscored by their applications in both basic and applied research, including development of novel therapeutics and elucidating disease mechanisms. These models provide researchers with the unique advantage of producing consistent and reproducible data that may not be achievable through transient transfection methodologies or traditional knockout techniques.
In comparison to other gene knockout systems, GGA2 Gene Knockout Cell Lines offer a streamlined approach for stable, long-term studies without the variability often associated with transient modifications. This specificity can significantly enhance the reliability of experimental outcomes, making it a favored choice among researchers in cellular and molecular biology.
For researchers and clinicians, these cell lines are invaluable, delivering insight into the physiological relevance of GGA2 and its potential as a target for innovative therapies. By employing GGA2 Gene Knockout Cell Lines, users can advance their understanding of complex biological systems and contribute to groundbreaking discoveries.
With years of experience in the development of high-quality biological products, our company is committed to providing researchers with robust cellular models tailored to accelerate scientific discovery and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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