Gene: GCNT2
Official Full Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)provided by HGNC
Gene Summary: This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05285 | GCNT2 Knockout cell line (HeLa) | Human | GCNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO05286 | GCNT2 Knockout cell line (HEK293) | Human | GCNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO05287 | GCNT2 Knockout cell line (A549) | Human | GCNT2 | 1:3~1:4 | Negative | Online Inquiry |
GCNT2 Gene Knockout Cell Lines are specialized genetic models designed for studying the functional roles of the GCNT2 gene, which codes for a critical enzyme involved in glycosylation processes. These cell lines have undergone targeted gene disruption using CRISPR/Cas9 technology, effectively eliminating the GCNT2 gene expression. This innovative approach enables researchers to explore the physiological and pathological implications of GCNT2 knockout, particularly in the context of glycan synthesis and signaling mechanisms.
The primary function of these knockout cell lines lies in their ability to facilitate investigations into the role of glycosylation in cell communication, immune response, and tumor progression. By studying these engineered cell lines, researchers can elucidate the impacts of GCNT2 absence on cellular behavior, such as adhesion, migration, and differentiation. Furthermore, they provide an invaluable tool for assessing the potential therapeutic targets related to various diseases, including cancer and immune disorders, where aberrant glycosylation patterns are frequently observed.
The scientific significance of GCNT2 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In laboratory settings, they enable deeper insights into biomolecular interactions and help refine drug development strategies aimed at modulating glycosylation for therapeutic benefits. Clinically, these models hold promise for advancing personalized medicine approaches, as understanding the role of specific genes can lead to more targeted interventions.
What sets our GCNT2 Gene Knockout Cell Lines apart from alternatives is their validated performance and comprehensive characterization, ensuring reliability in experimental outcomes. Our commitment to precision-engineered cell lines means that researchers can expect high-quality models that deliver reproducible results, reducing variability associated with less rigorously developed systems.
In addition, our company brings extensive expertise in molecular biology and genetic engineering, ensuring that our products are designed with a deep understanding of research needs and advancements in biotechnology. We are dedicated to providing top-tier biological tools that empower researchers and clinicians in their quest for discovery and innovation. The GCNT2 Gene Knockout Cell Lines stand as a testament to this commitment, offering a potent resource for advancing scientific understanding.
Please note that all services are for research use only. Not intended for any clinical use.
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