Gene: GALNT2
Official Full Name: polypeptide N-acetylgalactosaminyltransferase 2provided by HGNC
Gene Summary: This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37737 | GALNT2 Knockout cell line (HeLa) | Human | GALNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO37738 | GALNT2 Knockout cell line (HCT 116) | Human | GALNT2 | 1:2~1:4 | Negative | Online Inquiry |
KO37739 | GALNT2 Knockout cell line (HEK293) | Human | GALNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO37740 | GALNT2 Knockout cell line (A549) | Human | GALNT2 | 1:3~1:4 | Negative | Online Inquiry |
GALNT2 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of N-acetylgalactosaminyltransferase 2 (GALNT2), a critical enzyme involved in the glycosylation of proteins and lipids. These cell lines are specifically created to express a complete knockout of the GALNT2 gene, which allows researchers to investigate the functional consequences of this alteration on various cellular processes, including apoptosis, cell adhesion, and receptor signaling pathways.
These cell lines operate through the absence of GALNT2, leading to diminished O-glycosylation, which is vital in modulating cell surface receptor functions and influencing multiple signaling cascades. By eliminating this gene, researchers can observe the resultant phenotypic variations, providing insights into the underlying biological pathways and potential disease mechanisms related to altered glycosylation.
The scientific importance of GALNT2 Gene Knockout Cell Lines extends to critical research domains such as cancer biology, metabolic disorders, and neurodegenerative diseases, making them indispensable tools for both basic and applied research. They can also play a crucial role in drug discovery and the development of therapeutic strategies where glycosylation modifications are implicated.
What sets our GALNT2 Gene Knockout Cell Lines apart from conventional models is their precision in gene editing technology, ensuring high specificity and minimal off-target effects. This enhanced reliability allows for more reproducible results, thereby increasing the confidence in experimental findings. Furthermore, these knockout lines are available with customer support tailored to assist researchers in maximizing their experiments' potential.
In conclusion, GALNT2 Gene Knockout Cell Lines represent a significant advancement for researchers and clinicians seeking to unravel the complexities of glycosylation and its role in health and disease. Our company, with its commitment to cutting-edge research tools and a wealth of expertise in genetic engineering, is dedicated to supporting the scientific community in making groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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