Fgfr1 Knockout Cell Lines

Gene: FGFR1

Official Full Name: fibroblast growth factor receptor 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO01294	Fgfr1 Knockout cell line (H9c2(2-1))	Rat	Fgfr1	1:3~1:4	Negative	Online Inquiry

Background

FGFR1 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone precise genetic modification to inactivate the Fibroblast Growth Factor Receptor 1 (FGFR1) gene. These cell lines serve as pivotal tools in biological research, particularly in the study of cellular signaling pathways and developmental processes mediated by fibroblast growth factors. By knocking out the FGFR1 gene, researchers can elucidate the role of this receptor in various physiological and pathological contexts, including cancer, metabolism, and bone development.

The key mechanism of action relies on CRISPR-Cas9 technology or similar gene-editing strategies, which introduce targeted disruptions in the FGFR1 gene sequence. This functional disruption enables the study of resultant phenotypic changes, offering insights into how FGFR1 signaling impacts cell proliferation, differentiation, and apoptosis. In addition to basic research, FGFR1 gene knockout cell lines are increasingly recognized for their utility in drug discovery and development, allowing for the screening of potential therapeutics that modulate FGFR signaling pathways.

The scientific importance of these cell lines is underscored by their applications in both research laboratories and clinical settings. They facilitate the identification of biomarkers for FGFR-related diseases and contribute to a better understanding of treatment responses in patients with FGFR dysregulation.

What sets our FGFR1 Gene Knockout Cell Lines apart from alternatives is their high fidelity in gene editing, along with comprehensive validation to ensure consistent performance across experiments. Unlike non-specific or partial knockout models, these cell lines offer researchers the confidence needed to derive meaningful conclusions from their studies.

For researchers and clinicians looking to advance their understanding of FGFR1-related pathways or to discover novel therapeutic targets, our FGFR1 Gene Knockout Cell Lines present an invaluable resource. The reliability and specificity of our models can enhance the quality of research outcomes, ultimately accelerating the path from bench to bedside.

With our commitment to excellence in cell line development and a deep understanding of the complexities involved in signaling pathways, our company stands at the forefront of providing innovative biological products that empower scientific discovery and clinical advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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