Gene: FXYD5
Official Full Name: FXYD domain containing ion transport regulator 5provided by HGNC
Gene Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03138 | FXYD5 Knockout cell line (HeLa) | Human | FXYD5 | 1:3~1:6 | Negative | Online Inquiry |
KO03139 | FXYD5 Knockout cell line (HCT 116) | Human | FXYD5 | 1:2~1:4 | Negative | Online Inquiry |
KO03140 | FXYD5 Knockout cell line (HEK293) | Human | FXYD5 | 1:3~1:6 | Negative | Online Inquiry |
KO03141 | FXYD5 Knockout cell line (A549) | Human | FXYD5 | 1:3~1:4 | Negative | Online Inquiry |
FXYD5 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the FXYD5 gene, which plays a critical role in ion transport and cell signaling pathways. By using CRISPR-Cas9 technology, these cell lines allow researchers to study the physiological and pathological implications of FXYD5 dysregulation, thus providing insights into related diseases such as cancer and cardiac disorders.
The key function of these knockout cell lines lies in the deletion of the FXYD5 gene, resulting in altered ion channel functionality and cellular homeostasis. This gene knockout effectively models the effects of FXYD5 loss in various biological contexts, enabling detailed investigations into how its absence influences cellular proliferation, differentiation, and response to stress. Researchers can utilize these cell lines to perform functional assays, drug screenings, and biomarker discovery, thereby elucidating the role of FXYD5 in pathophysiological processes.
The scientific importance of FXYD5 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In preclinical studies, these models facilitate the evaluation of therapeutic targets and the development of novel treatment strategies for diseases associated with ion transport dysregulation. The data obtained can directly inform clinical decisions, enhancing the translation of findings from bench to bedside.
Compared to alternative models, which may not effectively replicate the nuances of FXYD5 function, our knockout cell lines provide a precise and reliable tool for researchers. The high specificity and efficiency of the CRISPR-Cas9 editing combined with our quality control measures ensure that the cell lines are validated and reproducible, significantly reducing the time and resources required for research.
Researchers and clinicians will find immense value in utilizing our FXYD5 Gene Knockout Cell Lines due to their ability to yield relevant and impactful data, ultimately driving forward the understanding of critical biological processes and disease mechanisms. At [Your Company Name], we pride ourselves on our cutting-edge genetic editing technologies and our commitment to supporting the scientific community with high-quality biological products tailored to meet the dynamic needs of research and development.
Please note that all services are for research use only. Not intended for any clinical use.
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