Gene: FXR1
Official Full Name: FMR1 autosomal homolog 1provided by HGNC
Gene Summary: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00507 | FXR1 knockout cell line (A549) | Human | FXR1 | 1:3~1:4 | Negative | Online Inquiry |
KO05519 | FXR1 Knockout cell line (HeLa) | Human | FXR1 | 1:3~1:6 | Negative | Online Inquiry |
KO05520 | FXR1 Knockout cell line (HCT 116) | Human | FXR1 | 1:2~1:4 | Negative | Online Inquiry |
KO05521 | FXR1 Knockout cell line (HEK293) | Human | FXR1 | 1:3~1:6 | Negative | Online Inquiry |
FXR1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the functional FXR1 gene, which encodes for the fragile X mental retardation 1 protein. These cell lines are particularly valuable for researchers studying the intricacies of gene regulation, RNA metabolism, and the pathophysiology of fragile X syndrome and other neurological disorders. By disabling the FXR1 gene, these cell lines provide a unique tool to investigate the consequences of its absence on cellular functions, including mRNA stability, translational control, and cellular signaling pathways.
The key mechanism underpinning the utility of FXR1 Gene Knockout Cell Lines lies in their ability to mimic the genetic conditions observed in fragile X syndrome while providing a controlled environment for experimentation. Researchers can use these knockouts to assess the roles of FXR1 in processes such as synaptic plasticity, neuronal growth, and RNA localization. Additionally, these cell lines can serve as a platform for testing potential therapeutic interventions targeting FXR1-related pathways, thereby accelerating the development of innovative treatments for associated disorders.
In scientific research and clinical settings, the relevance of FXR1 Gene Knockout Cell Lines is underscored by their applications in drug discovery, genetic modeling, and basic biology studies. Compared to alternative models, such as wild-type cell lines or transiently transfected systems, these knockout cell lines offer a stable and consistent genetic background, which significantly reduces variance in experimental outcomes and allows for more reproducible results. Researchers benefit from the ability to conduct more focused and precise experiments aimed at understanding disease mechanisms.
Furthermore, the specific advantages of utilizing FXR1 Gene Knockout Cell Lines lie in their ease of use, scalability for high-throughput screening, and compatibility with various assays, making them a versatile choice for both academic and pharmaceutical research. Their availability empowers researchers and clinicians to explore the fundamental aspects of gene function, with the potential for substantial breakthroughs in understanding and treating genetic disorders.
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Please note that all services are for research use only. Not intended for any clinical use.
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