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FUCA2 Knockout Cell Lines

Gene: FUCA2

Official Full Name: alpha-L-fucosidase 2provided by HGNC

Gene Summary: This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07081 FUCA2 Knockout cell line (HeLa) Human FUCA2 1:3~1:6 Negative Online Inquiry
KO07082 FUCA2 Knockout cell line (HCT 116) Human FUCA2 1:2~1:4 Negative Online Inquiry
KO07083 FUCA2 Knockout cell line (HEK293) Human FUCA2 1:3~1:6 Negative Online Inquiry
KO07084 FUCA2 Knockout cell line (A549) Human FUCA2 1:3~1:4 Negative Online Inquiry

Background

FUCA2 Gene Knockout Cell Lines are specialized cell lines that have undergone targeted genetic modification to disrupt the expression of the fucosyltransferase 2 (FUCA2) gene. This gene plays a crucial role in the fucosylation of glycoproteins and glycolipids, processes integral to cellular recognition, signaling, and immune responses. By utilizing powerful CRISPR/Cas9 gene-editing technology, these cell lines provide a precise tool to study the functional consequences of FUCA2 loss, enabling researchers to investigate its involvement in physiological and pathological contexts.

The key function of the FUCA2 Gene Knockout Cell Lines lies in the investigation of cellular processes influenced by fucosylation, including cell adhesion, migration, and the modulation of immune responses. By examining the phenotypic and molecular changes that occur upon FUCA2 knockout, scientists can uncover critical insights into various diseases, such as cancer, autoimmunity, and infectious diseases, where aberrant fucosylation may play a role. In clinical and translational research settings, these cell lines serve as invaluable platforms for drug discovery, biomarker identification, and the development of novel therapeutic strategies.

What sets our FUCA2 Gene Knockout Cell Lines apart from alternatives is their high efficiency and specificity achieved through our advanced gene-editing techniques. Each cell line is rigorously validated to ensure accurate knockout of the FUCA2 gene, significantly reducing the risk of off-target effects. Furthermore, these cell lines can be utilized across various backgrounds, including human and mouse cells, allowing for broad applicability in different research scenarios.

For researchers and clinicians focusing on glycosylation processes and their implications in health and disease, our FUCA2 Gene Knockout Cell Lines deliver unparalleled value. They empower users to push the boundaries of current understanding and foster innovative approaches to complex biological questions.

With years of experience in cellular biology and a commitment to delivering high-quality biological products, our company stands at the forefront of gene editing technologies. Our expertise ensures that researchers and clinicians receive not only the necessary tools but also the support needed to advance their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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