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FTL Knockout Cell Lines

Gene: FTL

Official Full Name: ferritin light chainprovided by HGNC

Gene Summary: This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00463 FTL knockout cell line (HeLa) Human FTL 1:3~1:6 Negative Online Inquiry
KO37778 FTL Knockout cell line (HCT 116) Human FTL 1:2~1:4 Negative Online Inquiry
KO37779 FTL Knockout cell line (HEK293) Human FTL 1:3~1:6 Negative Online Inquiry
KO37780 FTL Knockout cell line (A549) Human FTL 1:3~1:4 Negative Online Inquiry

Background

FTL Gene Knockout Cell Lines are genetically engineered cellular models that have undergone targeted deletion of the ferritin light chain (FTL) gene, a vital component involved in iron metabolism and storage. By disrupting the FTL gene, these cell lines allow for the investigation of iron homeostasis and its implications in various biological processes, including oxidative stress response, cellular metabolism, and disease mechanisms.

The primary function of FTL Gene Knockout Cell Lines is to provide researchers with a robust platform to explore the role of ferritin in cellular physiology and pathology. The knockout approach specifically enhances the understanding of how the absence of FTL influences iron overload, inflammatory responses, and related cytotoxicity. These cell lines enable detailed studies on the molecular pathways linked to ferroptosis, cancer progression, and neurodegenerative diseases, providing insights that could contribute to therapeutic advancements.

The scientific importance of these cell lines extends to both research and clinical applications. They serve as invaluable tools for drug discovery and testing, allowing for the assessment of novel therapeutics targeting iron metabolism and defining potential biomarkers for diseases associated with iron dysregulation. Researchers can utilize the FTL Gene Knockout Cell Lines to validate experimental hypotheses and develop preclinical models that mimic human pathophysiology.

In comparison to conventional cell lines, FTL Gene Knockout Cell Lines offer unique advantages, including a more precise manipulation of iron metabolism without the confounding effects observed in knockdown models or pharmacological inhibition. This specificity aids in generating reproducible results and enhances experimental validity, making these cell lines a preferred choice for researchers focused on iron biology.

The value of FTL Gene Knockout Cell Lines is pronounced, as they facilitate groundbreaking discoveries in iron-related research and clinical applications, potentially impacting treatments for conditions ranging from anemia to cancer. Our company prides itself on its commitment to providing high-quality, innovative biological products tailored to meet the needs of researchers and clinicians. With our expertise in genetic engineering and cell line development, we ensure our products support the advancement of scientific knowledge and therapeutic progress.

Please note that all services are for research use only. Not intended for any clinical use.

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