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FRRS1 Knockout Cell Lines

Gene: FRRS1

Official Full Name: ferric chelate reductase 1provided by HGNC

Gene Summary: Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17543 FRRS1 Knockout cell line (HeLa) Human FRRS1 1:3~1:6 Negative Online Inquiry
KO17544 FRRS1 Knockout cell line (HCT 116) Human FRRS1 1:2~1:4 Negative Online Inquiry
KO17545 FRRS1 Knockout cell line (HEK293) Human FRRS1 1:3~1:6 Negative Online Inquiry
KO17546 FRRS1 Knockout cell line (A549) Human FRRS1 1:3~1:4 Negative Online Inquiry

Background

FRRS1 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically disrupt the function of the Ferroreluctase 1 (FRRS1) gene. This product represents a powerful tool for investigating the role of FRRS1 in various biological processes, particularly its involvement in iron metabolism and cellular oxidative stress responses. By utilizing CRISPR-Cas9 technology, these cell lines provide a precise and efficient means of studying gene function and the resultant phenotypic alterations following gene knockout.

The key mechanism of the FRRS1 Gene Knockout Cell Lines lies in their ability to eliminate the FRRS1 protein expression, thereby enabling researchers to assess the downstream effects on cellular processes such as mitochondrial function and ferroptosis. These cell models facilitate the exploration of FRRS1's contributions to diseases associated with iron dysregulation, including neurodegenerative disorders and cancer, making them invaluable for both fundamental research and potential therapeutic development.

One of the significant advantages of the FRRS1 Gene Knockout Cell Lines over conventional wild-type cell models is their capacity to mimic the pathophysiological states influenced by the loss of FRRS1 function. This specificity allows for more accurate modeling of diseases and accelerates drug discovery efforts. Additionally, the reproducibility and reliability of these cell lines enhance experimental accuracy and facilitate comparative studies across laboratories.

Researchers and clinicians looking to delve into the genetics of iron metabolism or investigate disease mechanisms will find tremendous value in utilizing these cell lines. Their ability to provide clear insights into the biological interactions mediated by FRRS1 cannot be overstated, offering potential breakthroughs that could lead to novel therapeutic approaches.

With a commitment to advancing biomedical research, our company excels in providing high-quality genetic tools, including the FRRS1 Gene Knockout Cell Lines, ensuring that our products meet the rigorous standards of scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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