Gene: FRMD4A
Official Full Name: FERM domain containing 4Aprovided by HGNC
Gene Summary: This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17547 | FRMD4A Knockout cell line (HeLa) | Human | FRMD4A | 1:3~1:6 | Negative | Online Inquiry |
KO17548 | FRMD4A Knockout cell line (HCT 116) | Human | FRMD4A | 1:2~1:4 | Negative | Online Inquiry |
KO17549 | FRMD4A Knockout cell line (HEK293) | Human | FRMD4A | 1:3~1:6 | Negative | Online Inquiry |
KO17550 | FRMD4A Knockout cell line (A549) | Human | FRMD4A | 1:3~1:4 | Negative | Online Inquiry |
FRMD4A Gene Knockout Cell Lines are innovative, genetically engineered cell lines in which the FRMD4A gene has been inactivated or deleted, allowing researchers to study the gene's functional impacts on cellular behaviors. The FRMD4A gene encodes a protein believed to play a crucial role in various cellular processes, including cell signaling, adhesion, and cytoskeletal organization. By creating knockout models, scientists can elucidate the biological pathways reliant on FRMD4A, thus gaining crucial insights into its involvement in diseases, including cancer and neurodegenerative disorders.
The mechanisms underlying these cell lines hinge on advanced CRISPR/Cas9-based gene-editing technology, allowing for precise and efficient genomic alterations. Researchers can investigate FRMD4A's role in disease mechanisms and therapeutic responses by analyzing phenotypic changes, gene expression profiles, and cellular interactions in these engineered models. This targeted approach is instrumental in validating molecular targets for new treatments and enhancing our understanding of disease progression.
The FRMD4A Gene Knockout Cell Lines represent a significant advancement in genetic research, offering unparalleled specificity compared to traditional cell lines that lack defined genetic modifications. The uniqueness of these cell lines lies in their ability to reflect the absence of the FRMD4A gene, making them invaluable tools in dissecting the gene's function in real-time biological contexts.
Researchers and clinicians will find these knockout cell lines particularly beneficial as they seek to unravel complex gene interactions and explore novel therapeutic strategies. The precise and reproducible nature of our product enables robust and consistent experimental outcomes, allowing users to focus on generating impactful findings.
Our commitment to innovative biotechnology solutions empowers researchers with cutting-edge tools. With expertise in genetic engineering and cellular biology, our offerings are designed to facilitate groundbreaking research that advances the field of molecular biology and enhances its clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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