Gene: FPGT
Official Full Name: fucose-1-phosphate guanylyltransferaseprovided by HGNC
Gene Summary: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33861 | FPGT Knockout cell line (HeLa) | Human | FPGT | 1:3~1:6 | Negative | Online Inquiry |
KO33862 | FPGT Knockout cell line (HCT 116) | Human | FPGT | 1:2~1:4 | Negative | Online Inquiry |
KO33863 | FPGT Knockout cell line (HEK293) | Human | FPGT | 1:3~1:6 | Negative | Online Inquiry |
KO33864 | FPGT Knockout cell line (A549) | Human | FPGT | 1:3~1:4 | Negative | Online Inquiry |
FPGT Gene Knockout Cell Lines are genetically modified cell lines that have been precisely engineered to disrupt the function of the FPGT (Folate Polyglutamate Transporter) gene, a crucial component in folate metabolism and transport within cells. By specifically knocking out this gene, researchers can investigate the biochemical pathways that depend on folate availability, giving them insights into various metabolic diseases and potential therapeutic targets.
These cell lines function by implementing CRISPR/Cas9 technology, which provides a highly targeted approach to gene editing. This mechanism allows for the creation of stable cell lines that lack the FPGT protein, enabling comprehensive studies on the effects of folate deficiency at the cellular level. Researchers can use these models to explore cellular responses, signal transduction pathways, and the impact on cancer cell proliferation and drug resistance, making them invaluable for advancements in both fundamental and applied biomedical research.
The scientific importance of FPGT Gene Knockout Cell Lines cannot be overstated. They serve as a pivotal tool in the study of folate's role in health and disease, linking genetic factors to nutritional impairments and providing a model for understanding conditions such as cancer, cardiovascular diseases, and neurodevelopmental disorders. This product addresses the growing need for precise genetic models to elucidate the complexities of gene function in metabolic pathways.
Compared to traditional knockout models, FPGT Gene Knockout Cell Lines offer enhanced specificity and ease of use, with reduced off-target effects and a more streamlined ability to validate gene function. This specificity ensures that researchers can confidently draw conclusions regarding gene activity and its implications in health and disease.
By adopting FPGT Gene Knockout Cell Lines in your research or clinical investigations, you gain access to a powerful tool that facilitates groundbreaking discoveries and enhances the reliability of experimental results. These cell lines equip researchers and clinicians with the means to explore innovative therapeutic strategies, contributing significantly to the advancement of personalized medicine.
Our company prides itself on its commitment to excellence in genetic research products and innovative solutions tailored to meet the needs of the scientific community. With a strong background in molecular biology and a dedication to quality, we ensure our offerings are not only cutting-edge but also reliable and effective for all your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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