Gene: FOXE1
Official Full Name: forkhead box E1provided by HGNC
Gene Summary: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37848 | FOXE1 Knockout cell line (HeLa) | Human | FOXE1 | 1:3~1:6 | Negative | Online Inquiry |
KO37849 | FOXE1 Knockout cell line (HEK293) | Human | FOXE1 | 1:3~1:6 | Negative | Online Inquiry |
KO37850 | FOXE1 Knockout cell line (A549) | Human | FOXE1 | 1:3~1:4 | Negative | Online Inquiry |
FOXE1 Gene Knockout Cell Lines represent a powerful tool in genetic research and therapeutic development, specifically designed to study the function of the FOXE1 gene. This gene encodes a transcription factor vital for the development of the thyroid gland and is implicated in various physiological processes. By employing CRISPR/Cas9 technology, these knockout cell lines enable researchers to effectively silence the FOXE1 gene, providing a robust model system to dissect the downstream molecular pathways and physiological implications of FOXE1 deficiency.
The primary function of FOXE1 Gene Knockout Cell Lines lies in their ability to facilitate the in-depth exploration of FOXE1’s role in thyroid development and associated disorders, such as congenital hypothyroidism, as well as its potential link to thyroid cancer. These cell lines empower scientists to delineate the contribution of FOXE1 to cellular differentiation, proliferation, and gene expression modulation, thereby advancing our understanding of abnormal endocrine function.
The scientific relevance of these knockout cell lines extends to both basic and applied research settings, offering a crucial platform for drug screening and validation in therapeutic approaches. They are particularly advantageous for elucidating the intricate gene regulatory networks that underlie thyroid pathologies, thus supporting the quest for novel treatment strategies.
Compared to traditional methods, such as RNA interference, FOXE1 Gene Knockout Cell Lines provide a more stable and comprehensive gene modification, allowing for the observation of long-term effects without the risk of off-target effects commonly associated with transient knockdown techniques.
Researchers and clinicians can capitalize on the ease of use and reproducibility of results obtained from these cell lines, making them invaluable to studies aimed at understanding gene function and therapeutic interventions in thyroid-related diseases.
Our company is dedicated to providing high-quality biological research tools, backed by robust expertise in genetic engineering and cell line development. With our FOXE1 Gene Knockout Cell Lines, we equip scientists with cutting-edge resources to uncover the complex biology of gene function, enabling groundbreaking discoveries in the field of molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.