Gene: FMO4
Official Full Name: flavin containing dimethylaniline monoxygenase 4provided by HGNC
Gene Summary: Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37842 | FMO4 Knockout cell line (HCT 116) | Human | FMO4 | 1:2~1:4 | Negative | Online Inquiry |
KO37843 | FMO4 Knockout cell line (HEK293) | Human | FMO4 | 1:3~1:6 | Negative | Online Inquiry |
FMO4 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the Flavin-containing monooxygenase 4 (FMO4) gene and its biological implications. These cell lines are created by utilizing CRISPR/Cas9 technology to introduce targeted deletions within the FMO4 gene, effectively disrupting its expression. The knockout of this gene allows researchers to explore the roles and mechanisms of FMO4 in various metabolic processes, drug metabolism, and potential contributions to diseases.
The primary function of FMO4 lies in its role in the oxidation of nitrogen and sulfur-containing compounds, as well as in the biotransformation of therapeutic agents. By employing FMO4 Gene Knockout Cell Lines, scientists can elucidate how dysregulation of this enzyme affects pharmacokinetics and toxicity of certain pharmaceuticals. Additionally, these models are crucial for studies investigating the enzymatic pathways involved in the metabolism of endogenous compounds, providing a robust framework for clinical research and drug discovery.
The scientific importance of FMO4 Gene Knockout Cell Lines extends to their applications in pharmacology, toxicology, and personalized medicine. In research settings, they serve as a valuable tool for understanding the genetic factors influencing drug metabolism and variability in patient responses. Clinically, these knockout lines can help identify biomarkers for susceptibility to adverse drug reactions and in the development of safer drug formulations.
What sets FMO4 Gene Knockout Cell Lines apart from traditional models is their specificity and precision in gene targeting, coupled with the reproducibility and versatility afforded by the CRISPR technique. Unlike other genetic models that may introduce broad mutations, these engineered lines provide a focused approach to studying FMO4 interactions without confounding variables.
For researchers and clinicians seeking to deepen their understanding of drug metabolism and improve therapeutic outcomes, FMO4 Gene Knockout Cell Lines represent an invaluable asset. By harnessing these state-of-the-art models, users can expedite their research while potentially paving the way for advances in drug development.
Our company is committed to delivering high-quality biological research products, and our expertise in genetic engineering ensures that our FMO4 Gene Knockout Cell Lines meet rigorous scientific standards, empowering researchers to drive innovative discoveries in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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