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FMN2 Knockout Cell Lines

Gene: FMN2

Official Full Name: formin 2provided by HGNC

Gene Summary: This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17580 FMN2 Knockout cell line (HeLa) Human FMN2 1:3~1:6 Negative Online Inquiry
KO17581 FMN2 Knockout cell line (HEK293) Human FMN2 1:3~1:6 Negative Online Inquiry
KO17582 FMN2 Knockout cell line (A549) Human FMN2 1:3~1:4 Negative Online Inquiry

Background

FMN2 Gene Knockout Cell Lines are genetically modified cell lines designed to effectively silence the FMN2 gene, which encodes the protein Formins. This protein plays a critical role in the regulation of actin dynamics and is involved in cellular processes such as motility, growth, and division. By creating these knockout models, researchers can investigate the specific functions and associated pathways of FMN2 without the influence of its endogenous expression.

The primary function of FMN2 Gene Knockout Cell Lines is to facilitate the exploration of the biological roles that FMN2 plays in various cellular contexts. Through the processes of gene editing, researchers utilize CRISPR/Cas9 technology to induce frameshifts or deletions in the FMN2 locus, effectively leading to a loss of function. This allows scientists to study phenotypic changes in cell behavior, including alterations in cytoskeletal organization, cell signaling, and response to environmental stressors.

The scientific significance of these cell lines extends to their applications in understanding developmental biology, cancer research, and neurobiology. In clinical settings, insights derived from FMN2 studies could contribute to advances in targeted therapies for diseases linked to actin dysfunction, thereby broadening the therapeutic options for patients.

One of the notable advantages of using FMN2 Gene Knockout Cell Lines is their specificity. Unlike traditional methods that may utilize pharmacological inhibitors, these cell lines provide a clean genetic model free from off-target effects, leading to more reliable and reproducible results. This specificity, coupled with user-friendly protocols for maintenance and experimental application, sets our product apart from alternatives in the market.

Researchers and clinicians will find value in these cell lines due to their potential to unveil novel insights into the cellular mechanisms governed by FMN2. With a greater understanding of these pathways, they can pave the way for innovative treatments and diagnostic tools.

At our company, we are dedicated to delivering high-quality, reliable biological products that enhance research capabilities. Our expertise in genetic model systems ensures that you receive not only a robust experimental tool but also comprehensive support and guidance throughout your research journey.

Please note that all services are for research use only. Not intended for any clinical use.

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