Gene: FLRT2
Official Full Name: fibronectin leucine rich transmembrane protein 2provided by HGNC
Gene Summary: This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28975 | FLRT2 Knockout cell line (HeLa) | Human | FLRT2 | 1:3~1:6 | Negative | Online Inquiry |
KO28976 | FLRT2 Knockout cell line (HEK293) | Human | FLRT2 | 1:3~1:6 | Negative | Online Inquiry |
KO28977 | FLRT2 Knockout cell line (A549) | Human | FLRT2 | 1:3~1:4 | Negative | Online Inquiry |
FLRT2 Gene Knockout Cell Lines represent a pioneering advancement in the field of molecular biology and genetic research. These cell lines are specifically engineered to lack the FLRT2 gene, a member of the fibronectin leucine-rich repeat transmembrane (FLRT) family, which has been implicated in critical biological processes such as cell adhesion, migration, and proliferation. By providing a reliable model for studying the functional effects of FLRT2 knockout, these cell lines allow researchers to delineate its role in various cellular mechanisms, including neuronal development and tissue regeneration.
The unique mechanism of action inherent in FLRT2 gene knockout involves the complete absence of FLRT2 protein expression, thus facilitating investigations into the downstream signaling pathways and biological functions altered in its absence. Researchers can utilize these cell lines to explore the impact of FLRT2 on cellular behaviors and metabolic processes, paving the way for new discoveries in cell biology and developmental research.
From a scientific perspective, FLRT2 Gene Knockout Cell Lines are invaluable tools in both laboratory research and potential clinical applications. Their importance is underscored by the growing recognition of FLRT2's relevance in neurodevelopmental disorders and tumor biology, making them relevant for studies aimed at unraveling the etiology and progression of various diseases.
Compared to alternative models, such as wild-type cells or non-targeted gene editing, FLRT2 gene knockout cell lines provide a precise, one-step approach to gene disruption. This specificity reduces variability and enhances reproducibility, making experiments more robust and reliable. Furthermore, these models are readily available and can be seamlessly integrated into existing protocols, saving researchers both time and resources.
Investing in FLRT2 Gene Knockout Cell Lines empowers researchers and clinicians to advance their investigations with confidence. By focusing on a gene that plays a significant role in essential biological processes, users can leverage these cell lines to drive impactful research and potentially translate findings into therapeutic strategies.
Our company specializes in providing high-quality biological products that cater to the evolving needs of the scientific community. With extensive expertise in genetic tools and cell line development, we are dedicated to supporting your research endeavors with innovative, reliable solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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