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FHOD3 Knockout Cell Lines

Gene: FHOD3

Official Full Name: formin homology 2 domain containing 3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26143 FHOD3 Knockout cell line (HeLa) Human FHOD3 1:3~1:6 Negative Online Inquiry
KO26144 FHOD3 Knockout cell line (HCT 116) Human FHOD3 1:2~1:4 Negative Online Inquiry
KO26145 FHOD3 Knockout cell line (HEK293) Human FHOD3 1:3~1:6 Negative Online Inquiry
KO26146 FHOD3 Knockout cell line (A549) Human FHOD3 1:3~1:4 Negative Online Inquiry

Background

FHOD3 Gene Knockout Cell Lines represent a cutting-edge advancement in cellular biology, specifically designed to facilitate the study of the FHOD3 gene's role in various biochemical pathways and cellular functions. These cell lines consist of genetically modified cells in which the FHOD3 gene has been inactivated, providing researchers with a powerful tool to explore the consequences of its absence on cellular physiology, signal transduction, and overall organism health.

The primary function of FHOD3 primarily involves actin polymerization and cytoskeletal organization; thus, its knockout leads to significant alterations in cell morphology and motility. By utilizing these knockout cell lines, researchers can investigate the mechanistic implications of FHOD3 deficiency and its involvement in diseases such as cardiomyopathies and cancers, enabling unprecedented insights into potential therapeutic targets. The disruption of the FHOD3 gene can also affect cellular responses to external stimuli, thereby unlocking knowledge about cellular signaling pathways that are critical for proper development and function.

Scientifically, these knockout cell lines hold immense value in both research and clinical settings as they provide a model for studying diseases linked to cytoskeletal dysfunction. They are particularly useful in high-throughput screening for drug development, as compounds affecting FHOD3-related pathways could unveil novel treatments for cancer or cardiac disorders.

What sets FHOD3 Knockout Cell Lines apart from other genetic models is their specificity and reliability. While alternative models may exhibit off-target effects or inconsistently replicate the desired phenotypic changes, these knockout cell lines are rigorously validated to ensure the absence of the FHOD3 gene and its associated activities. This precision allows for more accurate and reproducible research outcomes, making them indispensable for any laboratory focused on cellular dynamics.

For researchers and clinicians alike, investing in FHOD3 Gene Knockout Cell Lines can significantly enhance the understanding of cytoskeletal involvement in health and disease, paving the way for innovative research breakthroughs. Our company specializes in providing high-quality biological products, ensuring that researchers have access to cutting-edge tools that help advance scientific knowledge and, ultimately, contribute to improved clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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