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FHL1 Knockout Cell Lines

Gene: FHL1

Official Full Name: four and a half LIM domains 1provided by HGNC

Gene Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01485 FHL1 Knockout cell line(HeLa) Human FHL1 1:3~1:6 Negative Online Inquiry
KO11304 FHL1 Knockout cell line (HCT 116) Human FHL1 1:2~1:4 Negative Online Inquiry
KO11305 FHL1 Knockout cell line (HEK293) Human FHL1 1:3~1:6 Negative Online Inquiry
KO11306 FHL1 Knockout cell line (A549) Human FHL1 1:3~1:4 Negative Online Inquiry

Background

FHL1 Gene Knockout Cell Lines represent a cutting-edge tool for researchers investigating the functional roles of the FHL1 gene in various biological processes, including muscle development, cell proliferation, and differentiation. These genetically modified cell lines are created through CRISPR/Cas9 gene editing technology, ensuring precise ablation of the FHL1 gene while minimizing off-target effects, which is critical for validating experimental results.

The core function of these knockout cell lines lies in their ability to facilitate in-depth studies of FHL1's gene regulatory roles, contributing insights into muscle-related diseases and certain cancers. By eliminating FHL1 expression, researchers can analyze downstream effects, signaling pathways, and gene interactions, providing a clearer understanding of cellular mechanisms. The cell lines also serve as a powerful model for drug screening and therapeutic development aimed at addressing disorders linked to altered FHL1 activity.

Scientifically, FHL1 Gene Knockout Cell Lines hold significant importance in both research and clinical settings. They allow translational studies to assess the implications of FHL1 loss in cellular context, paving the way for therapeutic interventions that target specific pathways influenced by this gene. The unique advantage of using these specialized knockout lines is that they provide researchers with a controlled environment that models the gene's absence, yielding reproducible and reliable data compared to studies utilizing wild-type cells.

For researchers and clinicians alike, the value of FHL1 Gene Knockout Cell Lines lies in their ability to answer pressing biological questions and to enhance the understanding of gene function in health and disease. This innovation enables a deeper exploration of the mechanisms behind various muscular and neoplastic conditions, ultimately driving forward the frontiers of biomedical science.

Our company is committed to advancing biological research by providing high-quality, precisely engineered cell lines like the FHL1 Gene Knockout Cell Lines, backed by extensive expertise in genetic engineering and molecular biology applications.

Please note that all services are for research use only. Not intended for any clinical use.

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