Home / FGF8 Knockout Cell Lines

FGF8 Knockout Cell Lines

Gene: FGF8

Official Full Name: fibroblast growth factor 8provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10796 FGF8 Knockout cell line (HCT 116) Human FGF8 1:2~1:4 Negative Online Inquiry
KO10797 FGF8 Knockout cell line (HEK293) Human FGF8 1:3~1:6 Negative Online Inquiry

Background

FGF8 Gene Knockout Cell Lines are engineered cellular models that have been specifically designed to lack the fibroblast growth factor 8 (FGF8) gene. FGF8 is known to play pivotal roles in development, tissue repair, and the regulation of various signaling pathways. By creating knockout variants, researchers can elucidate the gene's functions and its downstream effects on cellular behavior, facilitating a more profound understanding of developmental biology and potential therapeutic targets for various diseases.

These cell lines function by employing CRISPR-Cas9 technology, enabling precise edits to the genome and ensuring complete removal of the FGF8 gene. This strategic modification allows for the analysis of FGF8-dependent pathways and interactions, providing insight into its roles in processes such as angiogenesis, organogenesis, and cell differentiation. Researchers can utilize these knockout models to study how the absence of FGF8 influences cellular proliferation, migration, and signaling, which is crucial for advancing cancer research, regenerative medicine, and understanding congenital disorders.

The scientific importance of FGF8 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They serve as critical tools for dissecting the complexities of gene function and molecular interactions, making them invaluable in drug discovery and development. These models enable researchers to test hypotheses surrounding the role of FGF8 in various pathologies and support translational research efforts.

Compared to alternative methods—such as overexpression models or conventional gene silencing techniques—FGF8 knockout cell lines provide a more straightforward approach for gene function characterization due to their loss-of-function design, leading to stronger biological conclusions. Furthermore, these cell lines are ready-to-use, saving valuable time and resources for researchers.

For scientists, clinicians, and companies focusing on cutting-edge research, employing FGF8 Gene Knockout Cell Lines means accessing a reliable and robust platform that enhances the reliability and validity of experimental outcomes. The capacity to dissect complex biological processes with precision is indispensable in advancing scientific knowledge and fostering innovation.

As a leader in biotechnological advancements, our company specializes in providing high-quality, custom-engineered cell lines, ensuring that researchers have the tools they need to accelerate their discoveries in the life sciences. Our commitment to excellence and scientific rigor ensures that our products contribute meaningfully to the research community.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.