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FCHO1 Knockout Cell Lines

Gene: FCHO1

Official Full Name: FCH and mu domain containing endocytic adaptor 1provided by HGNC

Gene Summary: Enables AP-2 adaptor complex binding activity. Involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Located in cytosol; nucleoplasm; and plasma membrane. Is active in clathrin-coated pit. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29789 FCHO1 Knockout cell line (HeLa) Human FCHO1 1:3~1:6 Negative Online Inquiry
KO29790 FCHO1 Knockout cell line (HCT 116) Human FCHO1 1:2~1:4 Negative Online Inquiry
KO29791 FCHO1 Knockout cell line (HEK293) Human FCHO1 1:3~1:6 Negative Online Inquiry
KO29792 FCHO1 Knockout cell line (A549) Human FCHO1 1:3~1:4 Negative Online Inquiry

Background

FCHO1 Gene Knockout Cell Lines represent a pioneering advancement in the study of cellular dynamics and intracellular processes. These specialized cell lines are engineered to lack the FCHO1 gene, which encodes a protein essential for clathrin-mediated endocytosis, a vital mechanism for cellular uptake of various substances. By utilizing CRISPR/Cas9 technology for precise genome editing, these knockout cell lines provide researchers with unparalleled opportunities to elucidate the roles of FCHO1 in endosomal trafficking, membrane dynamics, and overall cellular homeostasis.

The key functionality of FCHO1 Gene Knockout Cell Lines lies in their ability to serve as robust experimental models for understanding the biochemical networks that govern cell signaling and nutrient uptake. With the loss of the FCHO1 protein, cellular responses can be closely examined, allowing scientists to explore the consequences of impaired endocytic pathways. This can lead to insights into conditions where these processes are dysregulated, including cancer, neurodegenerative diseases, and infections.

In both research and clinical settings, the utility of FCHO1 Gene Knockout Cell Lines is profound. They provide a critical tool for drug discovery, as changes in cellular responses to therapeutic agents can be studied in the context of altered endocytic pathways. Furthermore, the continuous pursuit of novel biomarkers and therapeutic targets hinge on understanding the molecular architecture within these cellular frameworks.

What sets FCHO1 Gene Knockout Cell Lines apart from alternative models is their specificity and efficiency. Other gene knockouts may involve off-target effects, but our product is rigorously validated to ensure precision in gene disruption. The availability of these cell lines accelerates the pace of research while minimizing variability typical in traditional models.

For researchers and clinicians alike, the FCHO1 Gene Knockout Cell Lines offer an invaluable resource to dive deeper into fundamental biological processes and their implications in disease. They not only enhance the quality of experimental data but also empower scientists to drive innovation in therapeutic strategies. Our company specializes in supplying high-quality biological products, underpinned by our commitment to advancing scientific discovery and supporting the research community in their quest for breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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