Gene: FBXW10B
Official Full Name: F-box and WD repeat domain containing 10Bprovided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17644 | FBXW10B Knockout cell line (HeLa) | Human | FBXW10B | 1:3~1:6 | Negative | Online Inquiry |
KO17645 | FBXW10B Knockout cell line (HCT 116) | Human | FBXW10B | 1:2~1:4 | Negative | Online Inquiry |
KO17646 | FBXW10B Knockout cell line (HEK293) | Human | FBXW10B | 1:3~1:6 | Negative | Online Inquiry |
KO17647 | FBXW10B Knockout cell line (A549) | Human | FBXW10B | 1:3~1:4 | Negative | Online Inquiry |
FBXW10B Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the FBXW10B gene, which encodes a protein involved in numerous cellular processes, including ubiquitin-mediated protein degradation and cell cycle regulation. This innovative product allows researchers to study the effects of FBXW10B absence in various biological contexts, facilitating a deeper understanding of gene function and its implications in health and disease.
These cell lines operate on the principle of CRISPR-Cas9 gene editing technology, which utilizes a guide RNA to specifically target and introduce double-strand breaks in the genes of interest, followed by homology-directed repair or non-homologous end joining that disrupts the target gene. By employing this method, FBXW10B Gene Knockout Cell Lines enable scientists to investigate the cellular pathways that are directly influenced by the FBXW10B protein, thus providing valuable insights into tumor biology, cell proliferation, and apoptosis.
The scientific importance of these knockout cell lines extends to their application in both basic and translational research settings. They serve as powerful models for validating hypotheses related to cancer biology, genetic disorders, and drug responses, allowing for the examination of therapeutic interventions targeting associated pathways. Moreover, the FBXW10B gene has been implicated in certain malignancies, making these cell lines particularly valuable for cancer research.
Compared to conventional gene knockout methods, the FBXW10B Gene Knockout Cell Lines offer robustness, reproducibility, and minimal off-target effects, ensuring more accurate experimental outcomes. The precision afforded by CRISPR technology, combined with the ready-to-use nature of these lines, provides researchers with efficient models that save time and resources.
This product is essential for researchers and clinicians aiming to uncover novel therapeutic targets and pathways in disease. By utilizing FBXW10B Gene Knockout Cell Lines, users can accelerate discoveries that may lead to significant advancements in medical science. Our company specializes in providing high-quality biological products that empower scientific research, backed by a team of experts dedicated to supporting your explorations in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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