Gene: FBXO43
Official Full Name: F-box protein 43provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05115 | FBXO43 Knockout cell line (HeLa) | Human | FBXO43 | 1:3~1:6 | Negative | Online Inquiry |
KO05116 | FBXO43 Knockout cell line (A549) | Human | FBXO43 | 1:3~1:4 | Negative | Online Inquiry |
FBXO43 Gene Knockout Cell Lines are expertly engineered cellular models specifically designed to facilitate in-depth exploration of the FBXO43 gene's function and its role in various biological processes. Utilizing advanced CRISPR-Cas9 genome editing technology, these cell lines allow researchers to create precise knockout variants, leading to the complete disruption of protein expression associated with the FBXO43 gene. By eliminating this gene, the cell lines serve as powerful tools for investigating cellular mechanisms influenced by FBXO43, including cell cycle regulation, DNA repair, and response to stress.
The mechanistic basis of these knockout cell lines lies in their ability to reveal the phenotypic consequences of FBXO43 loss. Researchers can study altered pathways and identify downstream effects that may contribute to disease states, such as cancer and neurodegenerative disorders. These cell lines have applications in pharmacological studies, biomarker discovery, and therapeutic development, providing critical insights that can drive translational research in both academic and clinical settings.
One of the distinct advantages of the FBXO43 Gene Knockout Cell Lines is their specificity and reliability compared to traditional gene knockdown methods, such as RNA interference, which can produce off-target effects or incomplete knockdowns. This high fidelity offers researchers confidence in their experimental outcomes and paves the way for more accurate interpretations of FBXO43’s biological relevance.
For researchers and clinicians keen on unlocking the complexities of gene function, the availability of high-quality FBXO43 knockout cell lines provides an invaluable resource that enhances experimental rigor and accelerates discovery efforts. Our company's commitment to precision and excellence in cellular models, backed by years of expertise in genetic engineering, ensures that you receive superior products tailored to meet the most demanding research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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