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FASTK Knockout Cell Lines

Gene: FASTK

Official Full Name: Fas activated serine/threonine kinaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02318 FASTK Knockout cell line (HeLa) Human FASTK 1:3~1:6 Negative Online Inquiry
KO02319 FASTK Knockout cell line (HCT 116) Human FASTK 1:2~1:4 Negative Online Inquiry
KO02320 FASTK Knockout cell line (HEK293) Human FASTK 1:3~1:6 Negative Online Inquiry
KO02321 FASTK Knockout cell line (A549) Human FASTK 1:3~1:4 Negative Online Inquiry

Background

FASTK Gene Knockout Cell Lines are specifically engineered cellular models designed to study the role and function of the FASTK gene, which is crucial for mitochondrial regulation and cellular metabolism. These cell lines have been developed using advanced CRISPR/Cas9 technology, enabling precise gene editing that results in the complete knockout of FASTK expression. As a result, researchers can investigate gene function, signaling pathways, and the impacts of FASTK on various cellular processes, facilitating deeper understanding of mitochondrial biogenesis and energy metabolism.

The primary mechanism by which FASTK Gene Knockout Cell Lines operate involves the disruption of FASTK gene transcription, leading to the absence of FASTK protein and consequential alterations in mitochondrial dynamics and RNA metabolism. This disruption allows scientists to observe inherent biological effects, providing insights into mitochondrial dysfunction linked to various diseases, including neurodegenerative disorders and metabolic syndromes.

In research and clinical settings, these knockout cell lines hold significant value for studying the pathophysiological mechanisms associated with mitochondrial impairment, offering a powerful tool for drug discovery and disease modeling. The ability to accurately mimic disease states in a controlled environment aids in the identification of novel biomarkers and therapeutic targets essential for advancing personalized medicine.

What sets FASTK Gene Knockout Cell Lines apart from traditional knockout models is their exceptional specificity and reproducibility, which minimizes off-target effects and enhances experimental reliability. Moreover, these cell lines are ready for immediate use, streamlining the research process and saving precious time for scientists.

By utilizing FASTK Gene Knockout Cell Lines, researchers and clinicians are equipped with a cutting-edge resource that furthers our understanding of mitochondrial function and its implications in health and disease. Our company leverages years of expertise in cellular engineering and molecular biology to provide high-quality biological products that meet the demands of contemporary scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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