Gene: Fas
Official Full Name: Fas cell surface death receptorprovided by MGI
Gene Summary: Enables identical protein binding activity. Involved in circadian rhythm; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including activation-induced cell death of T cells; cellular response to lithium ion; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10804 | FAS Knockout cell line (HeLa) | Human | FAS | 1:3~1:6 | Negative | Online Inquiry |
KO10805 | FAS Knockout cell line (HCT 116) | Human | FAS | 1:2~1:4 | Negative | Online Inquiry |
KO10806 | FAS Knockout cell line (HEK293) | Human | FAS | 1:3~1:6 | Negative | Online Inquiry |
KO10807 | FAS Knockout cell line (A549) | Human | FAS | 1:3~1:4 | Negative | Online Inquiry |
Fas Gene Knockout Cell Lines are genetically modified cell lines in which the Fas gene—known to play a crucial role in apoptotic signaling pathways—has been deliberately disrupted or "knocked out." This precise genetic alteration allows researchers to study the biological functions of the Fas receptor and its downstream signaling pathways in a controlled environment. By removing the gene responsible for modulating apoptosis, these cell lines become a vital tool for elucidating mechanisms of immune regulation, cell death, and tumor biology.
The functionality of Fas Gene Knockout Cell Lines lies in their ability to facilitate experiments designed to dissect the roles of apoptosis in various cellular contexts—ranging from normal cellular homeostasis to the pathogenesis of diseases such as cancer and autoimmune disorders. Researchers can investigate how the absence of Fas impacts cell survival, proliferation, and responses to chemotherapeutic agents, thereby gaining insights that could lead to innovative treatment strategies.
In research and clinical settings, Fas Gene Knockout Cell Lines are invaluable for studies aimed at therapeutic interventions, including the development of drugs that can modulate apoptosis for enhanced anticancer effects. By understanding the effects of gene knockout on cellular behaviors, scientists can better tailor therapeutic approaches for diseases characterized by dysfunctional apoptosis.
What sets these cell lines apart from alternatives is their specificity and reliability. Unlike transient knockdown techniques that may result in incomplete gene silencing, Fas Gene Knockout Cell Lines provide a stable and permanent model for research, ensuring reproducibility in experimental outcomes. Their robust performance has garnered trust in various laboratories, making them an essential resource in modern biomedical research.
For researchers and clinicians aiming to investigate apoptosis and its implications, Fas Gene Knockout Cell Lines offer a unique opportunity to advance scientific knowledge and innovation. Our company specializes in providing high-quality biological products supported by a commitment to research excellence and customer satisfaction. With a deep understanding of genetic modifications and cell culture, we ensure that our offerings meet the highest standards, empowering our clients to push the boundaries of discovery in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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