Gene: FAM111A
Official Full Name: FAM111 trypsin like peptidase Aprovided by HGNC
Gene Summary: The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20604 | FAM111A Knockout cell line (HeLa) | Human | FAM111A | 1:3~1:6 | Negative | Online Inquiry |
KO20605 | FAM111A Knockout cell line (HCT 116) | Human | FAM111A | 1:2~1:4 | Negative | Online Inquiry |
KO20606 | FAM111A Knockout cell line (HEK293) | Human | FAM111A | 1:3~1:6 | Negative | Online Inquiry |
KO20607 | FAM111A Knockout cell line (A549) | Human | FAM111A | 1:3~1:4 | Negative | Online Inquiry |
FAM111A Gene Knockout Cell Lines are genetically modified cell line models specifically engineered to lack the FAM111A gene, which encodes a protein involved in DNA replication and repair mechanisms. By utilizing CRISPR-Cas9 technology or other gene editing techniques, these cell lines enable researchers to investigate the biological functions of the FAM111A gene and its role in cellular processes, such as proliferation, apoptosis, and genomic stability.
The primary mechanism of these knockout cell lines involves the selective disruption of the FAM111A gene, leading to loss of its function. This alteration allows scientists to observe phenotypic changes and molecular pathways affected by the absence of the FAM111A protein. Such insights can reveal the gene's contributions to cancer biology, hereditary diseases, and cellular responses to stressors like DNA damage.
Scientifically, FAM111A gene knockout cell lines serve as crucial tools in both basic and translational research. Their usage spans a variety of applications, including drug development, gene therapy studies, and functional genomics, providing a platform to assess therapeutic targets and understand disease mechanisms. The insights gained from using these cell lines can accelerate the discovery of innovative treatments and diagnostic methods.
Compared to alternatives such as transient knockdown models or wild-type cell lines, FAM111A gene knockout cell lines offer the unique advantage of stable gene disruption, which allows for prolonged studies and reproducibility in experimental designs. This stability permits researchers to obtain more consistent and reliable data, particularly important in long-term experiments.
The value of FAM111A gene knockout cell lines lies in their ability to provide a clear understanding of the gene's functional implications, thereby empowering researchers and clinicians to make strides in their respective fields. Our company prides itself on delivering high-quality, rigorously validated biological products, backed by extensive expertise in genetic engineering and cell line development. By choosing FAM111A gene knockout cell lines, customers gain access to a powerful resource that enhances their research capabilities and fosters advancements in scientific knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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