Gene: FAAH2
Official Full Name: fatty acid amide hydrolase 2provided by HGNC
Gene Summary: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17846 | FAAH2 Knockout cell line (HeLa) | Human | FAAH2 | 1:3~1:6 | Negative | Online Inquiry |
KO17847 | FAAH2 Knockout cell line (HCT 116) | Human | FAAH2 | 1:2~1:4 | Negative | Online Inquiry |
KO17848 | FAAH2 Knockout cell line (HEK293) | Human | FAAH2 | 1:3~1:6 | Negative | Online Inquiry |
FAAH2 Gene Knockout Cell Lines represent a sophisticated tool for studying the fatty acid amide hydrolase 2 (FAAH2) gene, a critical component in lipid signaling pathways. These genetically engineered cell lines have been meticulously developed to facilitate the examination of FAAH2 functions by completely disrupting the gene's expression, providing researchers with a unique platform to investigate the physiological and biochemical effects of FAAH2 absence.
The primary mechanism underlying the functionality of these knockout cell lines involves the introduction of specific mutations that result in the loss of FAAH2 protein production. As FAAH2 is involved in the degradation of endocannabinoid signaling molecules, the knockout model allows for the exploration of how altered lipid signaling impacts various biological processes, including inflammation, pain modulation, and neurodegeneration. This insight is crucial for both academic research into basic biology and clinical advancements in therapeutic targets related to central nervous system disorders.
The scientific importance of FAAH2 Gene Knockout Cell Lines extends beyond just basic research; they have valuable applications in drug discovery and development, particularly in the field of cannabinoids and analgesics. Researchers can utilize these models to better understand the pharmacodynamics and pharmacokinetics of potential therapeutic agents that interact with the endocannabinoid system.
Compared to alternative methodologies that utilize wild-type or overexpressed cell lines, our FAAH2 Gene Knockout Cell Lines provide a more precise model that closely mimics the knockout conditions found in in vivo studies. This specificity results in more reliable and reproducible data, enhancing the overall quality of research outputs.
For researchers and clinicians focused on innovative therapeutic strategies in pain management and neurobiology, the FAAH2 Gene Knockout Cell Lines offer a compelling advantage by allowing for detailed mechanistic studies without the confounding effects presented by the presence of the FAAH2 enzyme.
At [Your Company Name], we pride ourselves on our commitment to advancing biological research through high-quality, precision-engineered products. Our expertise in genetic engineering ensures that our FAAH2 Gene Knockout Cell Lines are of the highest standard, ready to empower scientific discovery and foster innovative therapeutic applications.
Please note that all services are for research use only. Not intended for any clinical use.
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