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F2RL3 Knockout Cell Lines

Gene: F2RL3

Official Full Name: F2R like thrombin or trypsin receptor 3provided by HGNC

Gene Summary: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00006 F2RL3 Knockout cell line (Huh-7) Human F2RL3 1:2~1:3 Negative Online Inquiry
KO00972 F2RL3 Knockout cell line (Hep G2) Human F2RL3 1:2~1:4 Negative Online Inquiry

Background

F2RL3 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the F2RL3 gene, also known as the protease-activated receptor 3 (PAR3), which is implicated in various physiological and pathological processes. These knockout cell lines have been created through the targeted disruption of the F2RL3 gene using advanced genome-editing techniques, enabling researchers to understand its role in cell signaling pathways, inflammation, and immune response regulation.

The key function of F2RL3 Gene Knockout Cell Lines lies in their ability to provide insights into the mechanisms of F2RL3 deficiency. By studying these cell lines, scientists can observe alterations in cellular behavior, including changes in gene expression, metabolic activity, and overall cellular physiology. These knockout models allow for the elucidation of the biological consequences of F2RL3 knockouts, which can directly inform the understanding of disease mechanisms such as cardiovascular diseases, certain cancers, and immune disorders.

In the realm of research and clinical applications, these cell lines are invaluable for drug discovery and development. They provide a robust platform for testing therapeutic agents targeting the F2RL3 pathway and assessing their efficacy in relevant biological contexts. Moreover, by serving as a reference model for gene function studies, they enhance the depth of genetic research, potentially leading to breakthroughs in personalized medicine approaches.

Compared to alternative models, such as wild-type cell lines or transient knockdown systems, F2RL3 Gene Knockout Cell Lines offer stable gene disruption, ensuring reproducibility and consistency across experiments. This stability is crucial when investigating long-term effects of F2RL3 absence and evaluating therapeutic strategies.

Researchers and clinicians will find significant value in these cell lines as they streamline experimental workflows and deliver precise data about the F2RL3 gene's role in human health and disease. Our company possesses extensive expertise in genetic engineering and cell line development, ensuring high-quality, reliable products that empower scientific discovery and clinical innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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