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F2R Knockout Cell Lines

Gene: F2R

Official Full Name: coagulation factor II thrombin receptorprovided by HGNC

Gene Summary: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00007 F2R Knockout cell line (Huh-7) Human F2R 1:2~1:3 Negative Online Inquiry
KO00734 F2R Knockout cell line (Hep G2) Human F2R 1:2~1:4 Negative Online Inquiry
KO10365 F2R Knockout cell line (HeLa) Human F2R 1:3~1:6 Negative Online Inquiry
KO10366 F2R Knockout cell line (HCT 116) Human F2R 1:2~1:4 Negative Online Inquiry
KO10367 F2R Knockout cell line (HEK293) Human F2R 1:3~1:6 Negative Online Inquiry
KO10368 F2R Knockout cell line (A549) Human F2R 1:3~1:4 Negative Online Inquiry

Background

F2R Gene Knockout Cell Lines represent a significant advancement in cellular biology, specifically designed for the functional analysis of the F2R gene, which encodes the protease-activated receptor 1 (PAR1). Through precise genome editing techniques such as CRISPR-Cas9, these cell lines provide researchers with a robust platform to study gene function, cellular signaling pathways, and the pathophysiological roles of F2R in various biological systems.

The primary function of the F2R Gene Knockout Cell Lines lies in their ability to facilitate the investigation of PAR1's involvement in numerous biological processes, including inflammation, coagulation, and vascular regulation. The knockout approach effectively eliminates the expression of the F2R gene, allowing for the assessment of cellular responses in its absence. By contrasting these responses with those from wild-type controls, researchers can elucidate the specific contributions of PAR1 to various signaling cascades and disease states.

In terms of scientific importance, these cell lines serve as invaluable tools in both research and clinical settings. They enable the exploration of PAR1's roles in cancer progression, thrombosis, and cardiac diseases, thereby advancing our understanding of these conditions and paving the way for potential therapeutic interventions. Clinical researchers can leverage these knockout models to investigate drug responses and develop targeted therapies that modulate PAR1 signaling.

What sets F2R Gene Knockout Cell Lines apart from traditional cell models is their unparalleled specificity and reliability in gene manipulation. Unlike alternative models that may have residual gene expression or compensatory mechanisms, these knockout lines provide a clean slate to study PAR1's role without interference from other gene products. Additionally, they can be effectively used in high-throughput screening applications, thus accelerating the research timeline and enhancing experimental reproducibility.

For researchers and clinicians focused on understanding PAR1's role in health and disease, F2R Gene Knockout Cell Lines are indispensable. With their application potential spanning from basic research to clinical translation, these cell lines empower scientists to unlock the complexities of cellular mechanisms at the genetic level. Our company, with a commitment to delivering innovative biotechnological solutions, is proud to offer these high-quality cell lines tailored for advanced gene function studies, solidifying our position as a leader in the field of custom biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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