Gene: EYA4
Official Full Name: EYA transcriptional coactivator and phosphatase 4provided by HGNC
Gene Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37978 | EYA4 Knockout cell line (HeLa) | Human | EYA4 | 1:3~1:6 | Negative | Online Inquiry |
KO37979 | EYA4 Knockout cell line (HEK293) | Human | EYA4 | 1:3~1:6 | Negative | Online Inquiry |
KO37980 | EYA4 Knockout cell line (A549) | Human | EYA4 | 1:3~1:4 | Negative | Online Inquiry |
EYA4 Gene Knockout Cell Lines are specialized cellular models engineered to lack the EYA4 gene, which plays a pivotal role in the regulation of developmental processes and cellular differentiation. This gene is part of the Eyes Absent (EYA) family, known to influence various signaling pathways implicated in developmental biology and cancer. By utilizing CRISPR/Cas9 technology, these knockout cell lines allow researchers to study the functional consequences of EYA4 loss, enabling insights into its biological significance and potential links to various pathologies.
The key function of EYA4 Gene Knockout Cell Lines lies in their capacity to mimic the phenotypic and molecular characteristics associated with EYA4 deficiency. Their mechanisms include alterations in cellular signaling pathways, gene expression profiles, and developmental processes, making them invaluable for examining the gene's role in tissue development, regeneration, and tumorigenesis. Researchers can leverage these models to elucidate the pathways through which EYA4 operates, providing a Basis for the discovery of new therapeutic targets.
From a scientific perspective, these cell lines are critical tools in both basic research and translational studies. They have applications in cancer research, developmental biology, and gene therapy, fostering advancements in understanding how EYA4 contributes to diseases, particularly those involving developmental anomalies and cancers.
What sets our EYA4 Gene Knockout Cell Lines apart from alternative models is their rigorous validation, consistent performance, and ease of use. Unlike other knockout models that may exhibit off-target effects, our cell lines have undergone comprehensive quality control ensuring the integrity of gene deletion. Moreover, they are available in various cellular contexts, allowing researchers to select the most appropriate model for their specific study.
For researchers and clinicians, these knockout cell lines represent a valuable resource for exploring critical biological questions and developing innovative solutions. They empower scientists to draw meaningful conclusions about the role of EYA4 while facilitating the exploration of potential interventional strategies.
Our company prides itself on its commitment to excellence and innovation in biological research tools. We leverage advanced genetic engineering techniques and a deep understanding of cellular biology to provide researchers with high-quality products that enhance their scientific journey.
Please note that all services are for research use only. Not intended for any clinical use.
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