Gene: EXOG
Official Full Name: exo/endonuclease Gprovided by HGNC
Gene Summary: This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32469 | EXOG Knockout cell line (HeLa) | Human | EXOG | 1:3~1:6 | Negative | Online Inquiry |
KO32470 | EXOG Knockout cell line (HCT 116) | Human | EXOG | 1:2~1:4 | Negative | Online Inquiry |
KO32471 | EXOG Knockout cell line (HEK293) | Human | EXOG | 1:3~1:6 | Negative | Online Inquiry |
KO32472 | EXOG Knockout cell line (A549) | Human | EXOG | 1:3~1:4 | Negative | Online Inquiry |
EXOG Gene Knockout Cell Lines are specifically engineered cellular models designed to study the functional consequences of gene deletion of the EXOG gene, which encodes the enzyme Exonuclease 1. This crucial enzyme is involved in DNA repair and the processing of RNA molecules, thus playing a pivotal role in maintaining genomic stability and regulating cellular responses to stress. The knockout of the EXOG gene allows researchers to investigate its biological pathways and their implications in various cellular processes, including oncogenesis and cellular responses to treatment.
These cell lines operate through precise gene editing techniques, such as CRISPR-Cas9 or homologous recombination, to provide a tailored model system that can elucidate the specific roles of the EXOG gene without the confounding effects present in wild-type cells. This specificity allows for a clearer interpretation of experimental results, enhancing the understanding of gene function and regulation.
The scientific importance of EXOG Gene Knockout Cell Lines lies in their wide-ranging applications in basic and applied research, including cancer biology, gene function studies, and drug discovery. By enabling the interrogation of gene-specific functions, these models foster the development of targeted therapies, promoting advancements in personalized medicine.
Compared to traditional cell lines, the EXOG knockout variants offer enhanced fidelity for studying the loss-of-function phenotypes, enabling a more accurate assessment of gene interactions and pathways. Furthermore, they are accompanied by comprehensive data sets detailing their characterization and validation, streamlining the integration process into existing research frameworks.
For researchers and clinicians aiming to deepen their understanding of genomic stability and its implications in diseases, EXOG Gene Knockout Cell Lines provide invaluable insights. Their strategic employment can enhance experimental rigor and contribute to groundbreaking discoveries in molecular biology.
Our company boasts extensive expertise in the development and commercialization of advanced biological models, ensuring that our products meet the highest standards of quality and reliability. With a commitment to fostering scientific advancement, we offer tools that equip researchers to push the boundaries of knowledge in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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