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EVC2 Knockout Cell Lines

Gene: EVC2

Official Full Name: EvC ciliary complex subunit 2provided by HGNC

Gene Summary: This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10069 EVC2 Knockout cell line (A549) Human EVC2 1:3~1:4 Negative Online Inquiry

Background

EVC2 Gene Knockout Cell Lines are genetically engineered cell lines designed to knock out the EVC2 gene, which plays a significant role in ciliogenesis and cell signaling pathways. Eliminating the EVC2 gene provides researchers with a powerful tool for studying the underlying mechanisms of ciliopathies, a group of disorders associated with defective cilia function. The targeted knockout approach utilizes CRISPR-Cas9 technology, ensuring precision in gene editing and providing researchers with a reliable knockout model for functional studies.

These cell lines operate through a well-defined mechanism where the absence of the EVC2 gene disrupts normal protein interactions that are critical for ciliary structure and morphology. This disruption enables researchers to investigate the phenotypic consequences of EVC2 loss, facilitating insights into cellular processes such as cell motility, signaling, and differentiation. The applications of EVC2 Gene Knockout Cell Lines extend beyond fundamental research; they hold potential in drug discovery, toxicology studies, and genetic studies of EVC2-associated disorders.

One of the unique selling points of our EVC2 Gene Knockout Cell Lines is their high specificity and efficiency of gene disruption compared to alternative knockout models, such as those generated through traditional homologous recombination methods. This precision not only accelerates research timelines but also enhances the reproducibility of experimental results.

For researchers and clinicians focused on understanding ciliopathies and exploring therapeutic avenues, EVC2 Gene Knockout Cell Lines provide an invaluable resource that enables more accurate modeling of human diseases. The robust insights gained from these cell lines can drive advancements in targeted therapies and personalized medicine.

At our company, we pride ourselves on our expertise in providing high-quality biological products that are rigorously validated and tailored to meet the evolving needs of the scientific community. Our commitment to excellence ensures that our customers have access to the best tools available for their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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