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ERVFRD-1 Knockout Cell Lines

Gene: ERVFRD-1

Official Full Name: endogenous retrovirus group FRD member 1, envelopeprovided by HGNC

Gene Summary: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00522 ERVFRD-1 gRNA3-gRNA4 KO plasmid ERVFRD-1 $850
GP00686 ERVFRD-1 gRNA1-gRNA2 KO plasmid ERVFRD-1 $850
KO00787 ERVFRD-1 Knockout cell line(BeWo) Human ERVFRD-1 1:3~1:4 Negative Online Inquiry

Background

ERVFRD-1 Gene Knockout Cell Lines are a specialized type of genetically modified cell line designed to silence the ERVFRD-1 gene, which is implicated in various biological processes, including cellular response to stress, immune regulation, and tumorigenesis. These cell lines are generated through cutting-edge CRISPR-Cas9 technology, enabling precise and efficient knockout of the target gene, thereby allowing researchers to study the functional consequences of ERVFRD-1 depletion in vitro.

The primary mechanisms underlying the use of ERVFRD-1 Gene Knockout Cell Lines include the observation of phenotypic changes that result from the absence of the ERVFRD-1 protein. Researchers can investigate downstream signaling pathways, assess alterations in cell proliferation, apoptosis, and changes in metabolic pathways that are influenced by ERVFRD-1 activity. This in-depth examination of gene function is essential for elucidating the role of ERVFRD-1 in various biological contexts, particularly in relation to cancer biology and therapeutic resistance.

The scientific importance of these knockout cell lines extends to their applicability in both research and clinical settings. They provide powerful tools for understanding disease mechanisms, evaluating potential drug targets, and developing therapeutic strategies. For instance, insights gained from studies utilizing ERVFRD-1 knockout lines could inform the design of novel interventions in oncology where ERVFRD-1 contributes to tumor growth or therapeutic evasion.

What sets ERVFRD-1 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility, as well as the robustness of the CRISPR-Cas9 technique employed for gene editing. Researchers benefit from a time-efficient process that leads to reliable, consistent results, all while reducing off-target effects commonly associated with traditional genetic manipulation methods.

For researchers and clinicians, the value of ERVFRD-1 Gene Knockout Cell Lines lies in their potential to unlock new avenues of understanding in gene function and disease pathology, ultimately paving the way for innovative therapeutic strategies. With our company’s commitment to advancing genetic technologies and extensive experience in gene editing solutions, we stand poised to support the research community with cutting-edge biological products that drive discovery and enhance human health.

Please note that all services are for research use only. Not intended for any clinical use.

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