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ERO1B Knockout Cell Lines

Gene: ERO1B

Official Full Name: endoplasmic reticulum oxidoreductase 1 betaprovided by HGNC

Gene Summary: Enables protein-disulfide reductase activity and thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17894 ERO1B Knockout cell line (HCT 116) Human ERO1B 1:2~1:4 Negative Online Inquiry
KO17895 ERO1B Knockout cell line (HEK293) Human ERO1B 1:3~1:6 Negative Online Inquiry
KO17896 ERO1B Knockout cell line (A549) Human ERO1B 1:3~1:4 Negative Online Inquiry

Background

ERO1B Gene Knockout Cell Lines are genetically modified cell lines where the ERO1B gene, implicated in oxidative protein folding within the endoplasmic reticulum, has been specifically disrupted. This innovative product allows researchers to investigate the roles of ERO1B in cellular processes, notably in the response to oxidative stress and protein quality control. The knockout mechanism typically involves CRISPR-Cas9 technology, which provides precision in gene editing, facilitating the generation of cell lines that exhibit a loss of ERO1B function.

This product is crucial for scientific inquiry, offering insights into the pathophysiology of diseases associated with oxidative stress and protein misfolding, such as neurodegenerative disorders and various cancers. By using ERO1B Gene Knockout Cell Lines, researchers can elucidate the biochemical pathways dependent on ERO1B, test therapeutic hypotheses, and develop novel strategies for intervention in disease states. The ability to manipulate the ERO1B gene allows for a deeper understanding of its role in cellular signaling and stress responses.

Compared to conventional cell lines that do not possess these knockout modifications, ERO1B Gene Knockout Cell Lines stand out due to their specificity, reproducibility, and ability to mimic disease models more accurately. This targeted approach provides a robust platform for drug discovery and development.

For researchers and clinicians focused on oxidative stress signaling, protein folding diseases, or therapeutic interventions, ERO1B Gene Knockout Cell Lines offer invaluable tools for advancing scientific understanding and establishing new treatment modalities. Our company is committed to providing cutting-edge genetic models and resources, backed by extensive expertise in cellular biology and genetic engineering, to support your research endeavors effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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