Gene: ENOX2
Official Full Name: ecto-NOX disulfide-thiol exchanger 2provided by HGNC
Gene Summary: This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31787 | ENOX2 Knockout cell line (HeLa) | Human | ENOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO31788 | ENOX2 Knockout cell line (HCT 116) | Human | ENOX2 | 1:2~1:4 | Negative | Online Inquiry |
KO31789 | ENOX2 Knockout cell line (HEK293) | Human | ENOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO31790 | ENOX2 Knockout cell line (A549) | Human | ENOX2 | 1:3~1:4 | Negative | Online Inquiry |
ENOX2 Gene Knockout Cell Lines are meticulously engineered cellular models that have had the ENOX2 gene specifically disrupted, providing researchers with a powerful tool for studying the physiological and pathological roles of this gene in various biological contexts. The ENOX2 gene encodes an NADH oxidase, which is implicated in cancer progression and other diseases due to its role in modulating cellular oxidative stress and redox signaling pathways. By utilizing these knockout cell lines, researchers can observe the functional consequences of ENOX2 loss, elucidating its involvement in processes such as cell proliferation, apoptosis, and metastasis.
The mechanism underlying the utility of ENOX2 knockout cell lines lies in their ability to mimic a specific genetic alteration found in certain tumor types, providing an in vivo-like model for drug testing, biomarker discovery, and functional genomics studies. This knockout approach facilitates the assessment of ENOX2's contribution to the tumor microenvironment and interactions with other signaling pathways, offering insights that are critical for the development of targeted therapies.
The scientific importance of these cell lines extends to both research and clinical applications. In laboratories focusing on cancer biology, they enable the testing of therapeutic candidates aimed at ENOX2 modulation, while in translational research, they support the identification of biomarkers for patient stratification. Compared to traditional cell lines with intact ENOX2 expression, these knockout models deliver unparalleled specificity and relevance, enhancing the reliability of experimental outcomes.
Researchers and clinicians will find ENOX2 Gene Knockout Cell Lines invaluable due to their ability to provide clear and direct insights into the gene's functional dynamics, ultimately aiding in the design of innovative therapeutic strategies. Our company is committed to delivering high-quality, precision-engineered models, emphasizing our expertise in generating cutting-edge biological products that empower scientific discovery and drive advancements in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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