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EN1 Knockout Cell Lines

Gene: EN1

Official Full Name: engrailed homeobox 1provided by HGNC

Gene Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38037 EN1 Knockout cell line (HeLa) Human EN1 1:3~1:6 Negative Online Inquiry
KO38038 EN1 Knockout cell line (HEK293) Human EN1 1:3~1:6 Negative Online Inquiry

Background

EN1 Gene Knockout Cell Lines are a cutting-edge tool designed for advanced genetic research and functional genomics. These cell lines are engineered to have the EN1 (Engrailed homeobox 1) gene completely disabled, enabling scientists to study the gene's role in various biological processes, including cell differentiation, development, and neurogenesis. By providing insights into EN1's function, these knockout cell lines facilitate the exploration of its involvement in diseases such as cancer and neurodegenerative disorders.

The primary mechanism of action involves the targeted deletion of the EN1 gene using CRISPR/Cas9 technology, enabling precise alterations in the genome. This results in a robust model for examining changes in cellular behavior, protein interactions, and gene expression patterns that occur when EN1 is non-functional. Researchers can utilize these cell lines to investigate signaling pathways, cellular responses, and developmental cues that the EN1 gene regulates, leading to a deeper understanding of its biological significance.

The scientific importance of EN1 Gene Knockout Cell Lines extends to a wide range of applications in both research and clinical settings. They are invaluable tools for drug discovery, gene function analysis, and the validation of potential therapeutic targets. In addition, these cell lines serve as a foundation for the development of innovative treatment strategies aimed at modulating EN1-associated pathways.

What sets EN1 Gene Knockout Cell Lines apart from alternative products is their high specificity and reproducibility. While other gene knockout models may introduce off-target effects, our product is carefully validated to ensure accuracy in gene editing. Moreover, these cell lines come with comprehensive documentation and support, streamlining the integration into existing research projects.

For researchers and clinicians engaged in genetic and molecular biology, EN1 Gene Knockout Cell Lines offer a powerful tool for advancing our understanding of gene function and its implications in human health. Our company boasts extensive expertise in gene editing technologies and a commitment to providing high-quality biological products, ensuring that customers receive cutting-edge solutions that drive innovation and discovery in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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