Gene: EMP2
Official Full Name: epithelial membrane protein 2provided by HGNC
Gene Summary: This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05606 | EMP2 Knockout cell line (HeLa) | Human | EMP2 | 1:3~1:6 | Negative | Online Inquiry |
KO05607 | EMP2 Knockout cell line (HCT 116) | Human | EMP2 | 1:2~1:4 | Negative | Online Inquiry |
KO05608 | EMP2 Knockout cell line (HEK293) | Human | EMP2 | 1:3~1:6 | Negative | Online Inquiry |
KO05609 | EMP2 Knockout cell line (A549) | Human | EMP2 | 1:3~1:4 | Negative | Online Inquiry |
EMP2 Gene Knockout Cell Lines are a valuable biological tool designed to facilitate the study of the EMP2 gene, known for its roles in cellular processes such as proliferation, differentiation, and membrane dynamics. These cell lines have been meticulously engineered to exhibit a complete knockout of the EMP2 gene, allowing researchers to investigate the gene's function by observing the resultant phenotypic changes in cellular behavior and gene expression.
The primary function of EMP2 Gene Knockout Cell Lines lies in enabling a focused analysis of cellular pathways associated with the EMP2 protein. The knockout mechanism, typically achieved through CRISPR-Cas9 technology, results in the absence of EMP2, providing an optimal platform to explore its contribution to specific biological processes. Researchers can utilize these cell lines to dissect signaling pathways, test drug efficacy, and assess the role of EMP2 in various diseases, such as cancer and neurodegenerative disorders.
From a scientific perspective, these cell lines hold significant importance in both research and clinical settings. They provide an essential resource for elucidating gene function and molecular mechanisms underlying multiple pathological conditions. Moreover, they can be pivotal in the development of targeted therapeutics aimed at conditions linked to aberrant EMP2 expression.
Compared to traditional gene silencing methods, EMP2 Gene Knockout Cell Lines offer unmatched specificity and efficiency in gene disruption. The CRISPR-Cas9 technology utilized ensures precise editing, minimizing off-target effects, and providing consistent reproducibility across experiments. Furthermore, these cell lines are thoroughly validated to ensure high performance, making them a reliable choice for researchers.
For researchers and clinicians seeking to advance their understanding of EMP2-related pathways, these knockout cell lines represent an indispensable asset. Their purity, reliability, and innovative design will facilitate groundbreaking discoveries and enhance therapeutic advancements.
At our company, we pride ourselves on our expertise in developing high-quality biological products, combining cutting-edge technology with rigorous scientific validation to meet the evolving needs of the research community. Our EMP2 Gene Knockout Cell Lines exemplify our commitment to providing top-tier resources that empower researchers to unravel the complexities of gene function and regulation.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.