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EMC1 Knockout Cell Lines

Gene: EMC1

Official Full Name: ER membrane protein complex subunit 1provided by HGNC

Gene Summary: This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06190 EMC1 Knockout cell line (HeLa) Human EMC1 1:3~1:6 Negative Online Inquiry
KO06191 EMC1 Knockout cell line (HCT 116) Human EMC1 1:2~1:4 Negative Online Inquiry
KO06192 EMC1 Knockout cell line (HEK293) Human EMC1 1:3~1:6 Negative Online Inquiry
KO06193 EMC1 Knockout cell line (A549) Human EMC1 1:3~1:4 Negative Online Inquiry

Background

EMC1 Gene Knockout Cell Lines are genetically modified cell lines in which the EMC1 gene has been precisely disrupted using the CRISPR-Cas9 genome editing technology. The EMC1 gene, known for its role in endoplasmic reticulum (ER) function, intracellular signaling, and cell stress responses, serves as a critical target for studying various biological pathways, including immune responses and metabolic regulation. By knocking out the EMC1 gene, researchers can explore its impact on ER stress responses, cell proliferation, and apoptosis, thereby providing valuable insights into cellular mechanisms and disease pathology.

The key mechanism of action for these knockout cell lines involves silencing the EMC1 gene, leading to altered expression of downstream effectors involved in protein folding, degradation, and stress signaling pathways. This targeted approach allows for the dissection of pathways that are pivotal in various diseases, including cancer and neurodegenerative disorders. Consequently, these cell lines serve as essential tools in both basic and applied research, particularly in understanding the cellular response to stress and developing novel therapeutic strategies.

The scientific importance of EMC1 Gene Knockout Cell Lines lies in their applicability in drug discovery, disease modeling, and basic research into cellular stress responses. By providing a model for the exploration of the EMC1 gene's functional consequences, these cell lines facilitate the identification of potential therapeutic targets and biomarkers for diseases associated with ER dysfunction.

Compared to traditional cell lines or non-specific gene knockouts, EMC1 Gene Knockout Cell Lines offer unparalleled specificity and reliability, ensuring that researchers achieve reproducible results with greater accuracy. Our product guarantees high viability and stability, making them suitable for a myriad of experimental setups, including high-throughput screening and mechanistic studies.

For researchers and clinicians focused on cellular biology, cancer research, or drug development, the value of EMC1 Gene Knockout Cell Lines cannot be overstated. They not only streamline experimental workflows but also enhance the understanding of complex cellular processes and pave the way for innovative solutions in healthcare.

With a commitment to scientific excellence and innovation, our company specializes in providing high-quality biological products tailored to meet the diverse needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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