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ELK3 Knockout Cell Lines

Gene: ELK3

Official Full Name: ETS transcription factor ELK3provided by HGNC

Gene Summary: This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38056 ELK3 Knockout cell line (HeLa) Human ELK3 1:3~1:6 Negative Online Inquiry
KO38057 ELK3 Knockout cell line (HCT 116) Human ELK3 1:2~1:4 Negative Online Inquiry
KO38058 ELK3 Knockout cell line (HEK293) Human ELK3 1:3~1:6 Negative Online Inquiry
KO38059 ELK3 Knockout cell line (A549) Human ELK3 1:3~1:4 Negative Online Inquiry

Background

ELK3 Gene Knockout Cell Lines are expertly engineered cellular models specifically designed to facilitate the investigation of the ELK3 transcription factor's roles in various biological processes, including cellular growth, differentiation, and response to environmental stimuli. These knockout cell lines utilize CRISPR-Cas9 genome-editing technology to precisely disrupt the ELK3 gene, allowing researchers to study the gene's function by comparing the knockout lines with wild-type counterparts.

The primary function of ELK3 involves its regulatory influence on gene expression and its participation in signaling pathways that are important for developmental processes. By using ELK3 knockout cell lines, researchers can observe the resulting phenotypes, enabling a deeper understanding of the molecular mechanisms by which ELK3 contributes to cellular behavior. This knowledge is invaluable for elucidating the gene's role in various diseases, including cancers and neurodegenerative disorders, paving the way for potential therapeutic interventions.

The scientific importance of these cell lines extends to their applications in both basic research and translational studies. They serve as critical tools for drug screening, biomarker discovery, and functional genomics, offering insights into the pathophysiology associated with ELK3 dysregulation. Unlike conventional methods, the knockout approach provides a clean slate to explore downstream effects without the confounding influence of residual ELK3 activity.

What sets ELK3 Gene Knockout Cell Lines apart from alternatives is their precise knockout efficiency, scalability for high-throughput experimentation, and compatibility with a wide range of assays. Researchers benefit from a reliable and reproducible model system that saves time and resources while yielding high-quality data.

In summary, ELK3 Gene Knockout Cell Lines represent a powerful asset for researchers and clinicians aiming to unlock the complexities of gene regulation and its implications in health and disease. Our company, with its commitment to cutting-edge biotechnology solutions, offers these cell lines backed by a wealth of expertise in genetic engineering and cell biology, supporting our customers in their quest for scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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