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EIF2D Knockout Cell Lines

Gene: EIF2D

Official Full Name: eukaryotic translation initiation factor 2Dprovided by HGNC

Gene Summary: This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03751 EIF2D Knockout cell line (HeLa) Human EIF2D 1:3~1:6 Negative Online Inquiry
KO03752 EIF2D Knockout cell line (HCT 116) Human EIF2D 1:2~1:4 Negative Online Inquiry
KO03753 EIF2D Knockout cell line (HEK293) Human EIF2D 1:3~1:6 Negative Online Inquiry
KO03754 EIF2D Knockout cell line (A549) Human EIF2D 1:3~1:4 Negative Online Inquiry

Background

EIF2D Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to abrogate the expression of the EIF2D gene, a critical component of the eukaryotic translation initiation factor 2 (eIF2) family. By strategically disrupting the EIF2D gene, these knockout cell lines serve as invaluable tools for researchers studying the complex mechanisms of translational control, stress responses, and cellular differentiation.

The key function of the EIF2D Gene Knockout Cell Lines lies in their ability to provide a controlled environment for the investigation of protein synthesis modulation in the presence or absence of EIF2D activity. The disruption of this gene leads to alterations in the translation initiation complex, resulting in decreased protein synthesis under unfavorable conditions, such as nutrient deprivation or oxidative stress. As a result, these cell lines enable in-depth studies into mRNA translation dynamics and the resultant physiological responses of various cell types.

In research settings, these cell lines are of considerable scientific importance as they contribute significantly to our understanding of various diseases, including neurodegenerative disorders and cancer, where translational dysregulation is a hallmark. In clinical applications, EIF2D Gene Knockout Cell Lines can be used to assess the efficacy of therapeutic interventions aimed at restoring normal protein synthesis or alleviating stress responses.

Unlike traditional cell lines, our EIF2D Gene Knockout Cell Lines offer precision and reliability, ensuring that experiments yield reproducible results. Their specificity allows for targeted investigations without the confounding effects seen in non-knockout models. Moreover, these cell lines have been rigorously validated for performance and stability, setting a new standard in the field.

For researchers and clinicians seeking sophisticated tools to unravel the intricacies of gene regulation and protein synthesis, EIF2D Gene Knockout Cell Lines represent a groundbreaking resource. Our company is dedicated to advancing scientific discovery with a focus on innovation and excellence in providing high-quality biological products tailored to the needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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