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EIF2A Knockout Cell Lines

Gene: EIF2A

Official Full Name: eukaryotic translation initiation factor 2Aprovided by HGNC

Gene Summary: This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00317 EIF2A Knockout cell line (HeLa) Human EIF2A 1:3~1:6 Negative Online Inquiry
KO25301 EIF2A Knockout cell line (HCT 116) Human EIF2A 1:2~1:4 Negative Online Inquiry
KO25302 EIF2A Knockout cell line (HEK293) Human EIF2A 1:3~1:6 Negative Online Inquiry
KO25303 EIF2A Knockout cell line (A549) Human EIF2A 1:3~1:4 Negative Online Inquiry

Background

EIF2A Gene Knockout Cell Lines represent a pivotal advancement in molecular biology, providing researchers with a powerful tool for studying protein synthesis and cellular stress responses. These cell lines are specifically engineered to have a targeted knockout of the EIF2A gene, a key component of the eukaryotic translation initiation complex that plays a critical role in regulating the translation of mRNA into proteins during various cellular states, particularly under stress conditions.

The primary function of these knockout cell lines is to elucidate the mechanisms by which the EIF2A gene affects overall cellular behavior, including responses to stressors such as nutrient deprivation, oxidative stress, and viral infections. By removing the EIF2A gene’s expression, researchers can observe resultant changes in translation efficiency, cell viability, and pathway activation, providing deeper insights into the intricate network of cellular homeostasis and stress adaptation.

In scientific research and clinical settings, EIF2A Gene Knockout Cell Lines are invaluable for the development of therapies targeting dysregulated protein synthesis associated with diseases like cancer and neurodegeneration. The ability to manipulate protein synthesis pathways holds promise for novel treatment strategies and the design of specific inhibitors or stimuli that can modulate these processes.

One of the key advantages of our EIF2A Gene Knockout Cell Lines is their robustness and reproducibility. Unlike alternative methods that rely on transient transfection or gene silencing approaches, our knockout lines provide a stable and heritable model system that ensures consistent gene expression (or lack thereof) throughout experiments. Furthermore, these cell lines are extensively validated for their genomic integrity and functionality, which enhances confidence in experimental outcomes and data interpretation.

By choosing our EIF2A Gene Knockout Cell Lines, researchers gain access to a scientifically validated product that accelerates their understanding of fundamental biological processes and aids in the development of innovative therapeutic approaches. Our company is committed to providing high-quality biological products supported by extensive expertise in gene editing technology, ensuring that our customers have the best resources available to advance their research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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