Gene: EHD2
Official Full Name: EH domain containing 2provided by HGNC
Gene Summary: This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26730 | EHD2 Knockout cell line (HeLa) | Human | EHD2 | 1:3~1:6 | Negative | Online Inquiry |
KO26731 | EHD2 Knockout cell line (HCT 116) | Human | EHD2 | 1:2~1:4 | Negative | Online Inquiry |
KO26732 | EHD2 Knockout cell line (HEK293) | Human | EHD2 | 1:3~1:6 | Negative | Online Inquiry |
KO26733 | EHD2 Knockout cell line (A549) | Human | EHD2 | 1:3~1:4 | Negative | Online Inquiry |
EHD2 Gene Knockout Cell Lines are a powerful tool for researchers investigating the role of the EHD2 gene in various biological processes and disease mechanisms. EHD2, or EH-domain containing 2, is essential for endocytic trafficking, cellular signaling, and membrane dynamics. The knockout cell lines are created using CRISPR-Cas9 technology, which allows for precise gene editing, resulting in the elimination of EHD2 expression in a defined cellular background.
These cell lines function as a critical resource for elucidating the molecular pathways impacted by the absence of EHD2. They enable researchers to explore alterations in endocytosis, receptor recycling, and even the implications in cellular responses to extracellular signals. As EHD2 has been implicated in numerous pathological conditions, including cancer and neurodegenerative diseases, understanding its role through these knockout lines can provide insights into therapeutic targets and disease mechanisms.
The scientific importance of EHD2 Gene Knockout Cell Lines extends into both basic and translational research settings. Their applications range from mechanistic studies in cell biology to the development of targeted therapies. Researchers can use these models to validate hypotheses regarding EHD2-related pathways and screen for compounds that might restore normal function or impede disease progression.
What distinguishes EHD2 Gene Knockout Cell Lines from similar products is their rigorously validated background and user-friendly protocols for culture and analysis. The reliability of these cell lines ensures reproducibility in experiments, providing researchers with confidence in their results, unlike less meticulously characterized alternatives.
For scientists, clinicians, and biopharmaceutical companies, the value of EHD2 Gene Knockout Cell Lines lies in their ability to facilitate breakthroughs in understanding complex biological systems and finding novel therapeutic strategies. This product is essential for those aiming to translate in vitro findings into clinical insights.
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